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Case ReportCASE REPORTS AND CLINICAL OBSERVATIONS

Beyond Beck's Triad: A Rare Cause of Cardiac Tamponade and Hemoptysis

Homam Moussa Pacha, Mohamad Soud and M. Chadi Alraies
Ochsner Journal September 2018, 18 (3) 271-273; DOI: https://doi.org/10.31486/toj.17.0081
Homam Moussa Pacha
1Department of Internal Medicine, MedStar Washington Hospital Center, Washington,
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Mohamad Soud
1Department of Internal Medicine, MedStar Washington Hospital Center, Washington,
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M. Chadi Alraies
2Wayne State University, Detroit Medical Center Heart Hospital, Detroit,
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Abstract

Background: Primary cardiac angiosarcoma (CAS) is a rare tumor with a dismal prognosis. Many patients present with noncardiac symptoms related to metastatic disease that could delay the diagnosis and deteriorate the outcome.

Case Report: A 36-year-old male presented with hemoptysis. Initial imaging and biopsies were inconclusive, but a repeat transthoracic echocardiogram to evaluate the patient's pericardial effusion showed a mass inferior to the right atrium and invading the wall. Biopsy results from 3 different sites confirmed the diagnosis of CAS. However, the patient's course was complicated with respiratory failure that ultimately led to his death. Autopsy demonstrated CAS involving the full thickness of the right atrium and pericardial tissue, with a diffuse metastatic process involving the lung, brain, and stomach.

Conclusion: The case highlights the importance of having an increased level of suspicion for cardiac malignancy among young patients presenting with noncardiac symptoms.

Keywords:
  • Heart neoplasms
  • hemoptysis
  • sarcoma

INTRODUCTION

Primary cardiac tumors are rare, found in 0.02% of autopsies.1 While the majority of primary cardiac tumors are benign, 25% are malignant.2 Sarcomas account for 95% of malignant cardiac tumors, and one-third of them are cardiac angiosarcomas (CASs), the most common subtype.3,4 CASs are located predominantly in the right atrium,2 and patients commonly present with pericardial effusion with or without tamponade.5 In 1935, Dr Claude Beck described 2 triads of symptoms that aid in the diagnosis of cardiac tamponade: the acute tamponade triad (hypotension, venous distension, and diminished heart sounds) and the chronic compression triad (high venous pressure, ascites, and diminished heart sounds).6 Nevertheless, not uncommonly, CAS initially presents with noncardiac clinical symptoms, and in many cases, CAS is discovered on autopsy.2

CASE REPORT

A 36-year-old male presented with progressive dyspnea and hemoptysis for 2 weeks. Physical examination was remarkable for low-grade fever, distant heart sounds, and elevated jugular venous pressure. Chest x-ray showed multiple pulmonary nodules with right pleural effusion (Figure, A). Computed tomography (CT) of the chest revealed bilateral innumerable diffuse pulmonary nodules and large pericardial effusion (Figure, B). Transthoracic echocardiogram (TTE) was remarkable for large pericardial effusion with right ventricular and atrial diastolic compression, indicating early tamponade (Figure, C). Urgent pericardiocentesis removed 1,500 cc of bloody pericardial fluid. Fluids analysis showed an exudative fluid with inflammatory cells with cytology negative for malignancy or infection. Extensive rheumatologic and infectious workups were negative. CT-guided and endobronchial ultrasound-guided biopsy were inconclusive. Repeat TTE to evaluate the pericardial effusion showed a mass inferior to the right atrium and invading the wall that was not seen on the previous TTE (Figure, D). Given this new echocardiographic finding and the patient's clinical presentation, suspicion of metastatic lung nodules secondary to primary cardiac tumor was high. The patient was referred for video-assisted thoracoscopic surgery. Biopsy results from 3 different sites confirmed the diagnosis of CAS. However, the patient's course was complicated with respiratory failure that ultimately led to his death. Autopsy demonstrated CAS involving the full thickness of the right atrium and pericardial tissue, with a diffuse metastatic process involving the lung, brain, and stomach.

Figure. A:
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Figure. A: Chest x-ray shows multiple pulmonary nodules with right pleural effusion. B: Computed tomography of the chest shows bilateral innumerable diffuse pulmonary nodules and large pericardial effusion. C: Transthoracic echocardiogram (TTE) shows large pericardial effusion with signs suggesting early tamponade. D: Repeat TTE shows a mass invading the right atrium (RA) wall (arrows and asterisks). IVC, inferior vena cava.

DISCUSSION

CAS is a fatal tumor that has nonspecific presentations other than the typical presentations of pericardial effusion and right-sided heart failure; hemoptysis is one of the nonspecific symptoms.5,7 Many patients present with noncardiac symptoms related to metastatic disease involving the lung, liver, bones, and other organs.4,5,8 A series of 18 CAS cases showed pericardial effusion to be the most common presentation.5 Median overall survival was 13 months in the entire cohort; among patients with CAS, median survival was 6 months compared to 19.5 months for patients with a localized tumor.5 Because of the tendency for early metastasis, CAS has a poor prognosis, with median survival dependent on the extent of the disease and response to therapy.4,5,8

Echocardiogram sensitivity in detecting CAS can reach 75%;9 advanced imaging such as cardiac magnetic resonance imaging adds great value in differentiating between benign and malignant masses.10 However, a tissue biopsy is needed to confirm the diagnosis, either open biopsy for operable tumors or transvenous endomyocardial biopsy for inoperable tumors.

Multimodality therapies for CAS—including surgical resection, radiotherapy, and chemotherapy—are evolving, and the lack of a defined systemic therapy is attributed to the rarity of the disease.4,5 Complete surgical resection of localized disease is considered the most effective treatment and has been shown to improve survival.4,5,8 A study of 13 patients with CAS demonstrated that combined therapy of surgical resection and chemoradiotherapy had the best prognosis.8 The use of radiotherapy in CAS is challenging because of the risk of radiotherapy-induced cardiac toxicity in the form of pericarditis and cardiomyopathy.11

CONCLUSION

Primary CAS is a rare and challenging tumor with a dismal prognosis. Metastasis with nonspecific symptoms as the initial presentation is not uncommon. Many patients present with symptoms related to metastatic disease that could delay the diagnosis and deteriorate the outcome despite multimodality imaging.

This article meets the Accreditation Council for Graduate Medical Education and the American Board of Medical Specialties Maintenance of Certification competencies for Patient Care and Medical Knowledge.

ACKNOWLEDGMENTS

The authors have no financial or proprietary interest in the subject matter of this article.

  • © Academic Division of Ochsner Clinic Foundation

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Beyond Beck's Triad: A Rare Cause of Cardiac Tamponade and Hemoptysis
Homam Moussa Pacha, Mohamad Soud, M. Chadi Alraies
Ochsner Journal Sep 2018, 18 (3) 271-273; DOI: 10.31486/toj.17.0081

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Beyond Beck's Triad: A Rare Cause of Cardiac Tamponade and Hemoptysis
Homam Moussa Pacha, Mohamad Soud, M. Chadi Alraies
Ochsner Journal Sep 2018, 18 (3) 271-273; DOI: 10.31486/toj.17.0081
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