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Case ReportCASE REPORTS AND CLINICAL OBSERVATIONS

Prolonged Activated Clotting Time Immediately Prior to Open Cardiac Surgery

Sarah M. Baker, Ashley Kiefer, Dominic S. Carollo and Rajasekharan P. Warrier
Ochsner Journal December 2018, 18 (4) 423-424; DOI: https://doi.org/10.31486/toj.18.0087
Sarah M. Baker
1Department of Microbiology and Immunology, Tulane University School of Medicine, ,
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Ashley Kiefer
2Le Bonheur Children’s Hospital, University of Tennessee, ,
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Dominic S. Carollo
3Department of Anesthesiology, Ochsner Clinic Foundation, ,
4The University of Queensland School of Medicine, Ochsner Clinical School, ,
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Rajasekharan P. Warrier
4The University of Queensland School of Medicine, Ochsner Clinical School, ,
5Department of Pediatrics, Ochsner Clinic Foundation, ,
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  • For correspondence: rwarrier@ochsner.org
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REFERENCES

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    . Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein. J Clin Invest. 1977 Jul;60(1):18-31.
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    1. Girolami A,
    2. Scarparo P,
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    4. Lombardi AM
    . Congenital prekallikrein deficiency. Expert Rev Hematol. 2010 Dec;3(6):685-695. doi: 10.1586/ehm.10.69.
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    1. Dasanu CA,
    2. Alexandrescu DT
    . A case of prekallikrein deficiency resulting in severe recurrent mucosal hemorrhage. Am J Med Sci. 2009 Nov;338(5):429-430. doi: 10.1097/MAJ.0b013e3181b270bb.
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    1. Girolami A,
    2. Ferrari S,
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    . Prevalence of hypertension and its complications in congenital prekallikrein deficiency: analysis of all reported cases and clinical significance. Blood Coagul Fibrinolysis. 2015 Jul;26(5):560-563. doi: 10.1097/MBC.0000000000000294.
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    1. Bojanini EU,
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    . Prekallikrein deficiency presenting as recurrent cerebrovascular accident: case report and review of the literature. Case Rep Hematol. 2012;2012:723204. doi: 10.1155/2012/723204.
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    1. Sugi T,
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    . Factor XII, kininogen and plasma prekallikrein in abnormal pregnancies. Curr Drug Targets. 2005 Aug;6(5):551-557.
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  9. 9.↵
    1. Odumosu MC,
    2. Yoong WC,
    3. Fakokunde AF
    . Fletcher factor deficiency in a woman requiring emergency caesarean section. J Obstet Gynaecol. 2009 Jul;29(5):442. doi: 10.1080/01443610902952554.
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  10. 10.↵
    1. Oram MP,
    2. Mumford AD,
    3. Morse C,
    4. Underwood S
    . Management of anticoagulation for coronary artery bypass surgery in a patient with severe prekallikrein deficiency. J Cardiothorac Vasc Anesth. 2006 Aug;20(4):580-582.
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  11. 11.↵
    1. Lämmle B,
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    Thromboembolism and bleeding tendency in congenital factor XII deficiency–a study on 74 subjects from 14 Swiss families. Thromb Haemost. 1991 Feb 12;65(2):117-121.
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Ochsner Journal: 18 (4)
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Dec 2018
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Prolonged Activated Clotting Time Immediately Prior to Open Cardiac Surgery
Sarah M. Baker, Ashley Kiefer, Dominic S. Carollo, Rajasekharan P. Warrier
Ochsner Journal Dec 2018, 18 (4) 423-424; DOI: 10.31486/toj.18.0087

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Prolonged Activated Clotting Time Immediately Prior to Open Cardiac Surgery
Sarah M. Baker, Ashley Kiefer, Dominic S. Carollo, Rajasekharan P. Warrier
Ochsner Journal Dec 2018, 18 (4) 423-424; DOI: 10.31486/toj.18.0087
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Keywords

  • Factor XIIa
  • prekallikrein
  • prekallikrein deficiency

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