PT  - JOURNAL ARTICLE
AU  - Li Li
AU  - John Cole
AU  - David A. Margolin
TI  - Cancer Stem Cell and Stromal Microenvironment
DP  - 2013 Mar 20
TA  - Ochsner Journal
PG  - 109--118
VI  - 13
IP  - 1
4099  - http://www.ochsnerjournal.org/content/13/1/109.short
4100  - http://www.ochsnerjournal.org/content/13/1/109.full
SO  - Ochsner J2013 Mar 20; 13
AB  - Background Chemotherapeutic resistance and local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional cancer treatments do not consistently prevent cancer recurrence.Methods We illustrate the key roles that cancer stem cells and the tumor microenvironment—particularly the lymph node stromal microenvironment—play in tumor drug resistance, metastasis, and recurrence in 2 representative cancers: colorectal cancer and follicular lymphoma.Conclusion We believe that combination treatment with chemotherapeutic agents in conjunction with targeted therapies, such as stromal/cancer stem cell signaling–targeted therapy, may effectively minimize cancer recurrence.