RT Journal Article
SR Electronic
T1 Cancer Stem Cell and Stromal Microenvironment
JF Ochsner Journal
JO Ochsner J
FD O. P. Jindal Global University
SP 109
OP 118
VO 13
IS 1
A1 Li Li
A1 John Cole
A1 David A. Margolin
YR 2013
UL http://www.ochsnerjournal.org/content/13/1/109.abstract
AB Background Chemotherapeutic resistance and local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional cancer treatments do not consistently prevent cancer recurrence.Methods We illustrate the key roles that cancer stem cells and the tumor microenvironment—particularly the lymph node stromal microenvironment—play in tumor drug resistance, metastasis, and recurrence in 2 representative cancers: colorectal cancer and follicular lymphoma.Conclusion We believe that combination treatment with chemotherapeutic agents in conjunction with targeted therapies, such as stromal/cancer stem cell signaling–targeted therapy, may effectively minimize cancer recurrence.