PT  - JOURNAL ARTICLE
AU  - Tammuella Chrisentery Singleton
AU  - Matthew Keane
TI  - Diagnostic and Therapeutic Challenges of Intracranial Hemorrhage in Neonates With Congenital Hemophilia: A Case Report and Review
DP  - 2012 Sep 21
TA  - Ochsner Journal
PG  - 249--253
VI  - 12
IP  - 3
4099  - http://www.ochsnerjournal.org/content/12/3/249.short
4100  - http://www.ochsnerjournal.org/content/12/3/249.full
SO  - Ochsner J2012 Sep 21; 12
AB  - Intracranial hemorrhage (ICH) in full-term neonates with hemophilia is uncommon. Retrospective studies estimate the incidence to be 3.4%-4.0%. However, ICH is the second most common initial hemorrhage for all infants with congenital hemophilia. Nearly half (41%) of the hemorrhages occur within the first week of life, and most hemorrhages are related to traumatic deliveries. But clinical signs of ICH in neonates are difficult to assess and often result in a delay in the diagnosis. The timely diagnosis of ICH is critical; however, the early and intensive factor replacement therapy that the patient needs is associated with the risk of inhibitor formation. We report a case of ICH in a neonate with severe hemophilia A, no family history, and inhibitor development after intensive therapy.