RT Journal Article
SR Electronic
T1 Diagnostic and Therapeutic Challenges of Intracranial Hemorrhage in Neonates With Congenital Hemophilia: A Case Report and Review
JF Ochsner Journal
JO Ochsner J
FD O. P. Jindal Global University
SP 249
OP 253
VO 12
IS 3
A1 Tammuella Chrisentery Singleton
A1 Matthew Keane
YR 2012
UL http://www.ochsnerjournal.org/content/12/3/249.abstract
AB Intracranial hemorrhage (ICH) in full-term neonates with hemophilia is uncommon. Retrospective studies estimate the incidence to be 3.4%-4.0%. However, ICH is the second most common initial hemorrhage for all infants with congenital hemophilia. Nearly half (41%) of the hemorrhages occur within the first week of life, and most hemorrhages are related to traumatic deliveries. But clinical signs of ICH in neonates are difficult to assess and often result in a delay in the diagnosis. The timely diagnosis of ICH is critical; however, the early and intensive factor replacement therapy that the patient needs is associated with the risk of inhibitor formation. We report a case of ICH in a neonate with severe hemophilia A, no family history, and inhibitor development after intensive therapy.