PT - JOURNAL ARTICLE AU - Eboni G. Price-Haywood TI - Clinical Comparative Effectiveness Research Through the Lens of Healthcare Decisionmakers DP - 2015 Jun 20 TA - Ochsner Journal PG - 154--161 VI - 15 IP - 2 4099 - http://www.ochsnerjournal.org/content/15/2/154.short 4100 - http://www.ochsnerjournal.org/content/15/2/154.full SO - Ochsner J2015 Jun 20; 15 AB - Background Healthcare expenditures in the United States exceed the healthcare expenditures of other countries, yet relatively unfavorable health outcomes persist. Despite the emergence of numerous evidence-based interventions, wide variations in clinical care have caused disparities in quality of care and cost. Comparative effectiveness and cost effectiveness research may better guide healthcare decisionmakers in determining which interventions work best, for which populations, under which conditions, and at what cost.Methods This article reviews national health policies that promote comparative effectiveness research (CER), healthcare decisionmaker roles in CER, methodological approaches to CER, and future implications of CER.Results This article provides a brief summary of CER health policy up to the Patient Protection and Affordable Care Act and its establishment of the Patient-Centered Outcomes Research Institute (PCORI). Through PCORI, participatory methods for engaging healthcare decisionmakers in the entire CER process have gained momentum as a strategy for improving the relevance of research and expediting the translation of research into practice. Well-designed, methodologically rigorous observational studies and randomized trials conducted in real-world settings have the potential to improve the quality, generalizability, and transferability of study findings.Conclusion Learning health systems and practice-based research networks provide the infrastructure for advancing CER methods, generating local solutions to high-quality cost-effective care, and transitioning research into implementation and dissemination science—all of which will ultimately guide health policy on clinical care, payment for care, and population health.