%0 Journal Article %A Jody H. Haddock %A Donald E. Mercante %A Rose Paccione %A Jacob L. Breaux %A Sarah E. Jolley %A Jessica L. Johnson %A Sean E. Connolly %A Bennett P. deBoisblanc %T Use of Digital Pupillometry to Measure Sedative Response to Propofol %D 2017 %J Ochsner Journal %P 250-253 %V 17 %N 3 %X Background: Digital pupillometry (DP) accurately and precisely measures pupillary responses. Little is known about using DP to measure the sedative effect of isolated propofol administration.Methods: We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.Results: Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination ā€“1.24 mm, standard error [SE] 0.25 and ā€“0.79 mm, SE 0.13, respectively; Pā‰¤0.001 for both). Mean constriction velocity decreased by 0.84 mm/s between baseline and procedural termination (P=0.001). Pupillary latency increased significantly between baseline and induction (mean change 0.016 seconds, SE 0.007; P=0.04) but was not significantly different at other time points.Conclusion: We speculate that DP may be a useful tool to monitor propofol sedation. %U https://www.ochsnerjournal.org/content/ochjnl/17/3/250.full.pdf