RT Journal Article SR Electronic T1 Periampullary Carcinoma: Unusual Sites of Metastasis JF Ochsner Journal JO Ochsner J FD O. P. Jindal Global University SP 426 OP 429 VO 17 IS 4 A1 Anju Bansal A1 Varsha Dalal A1 Manveen Kaur A1 Fouzia Siraj YR 2017 UL http://www.ochsnerjournal.org/content/17/4/426.abstract AB Background: Periampullary neoplasms include carcinomas of the duodenum, ampulla of Vater, distal common bile duct, and pancreas. The aggressive course of these neoplasms is attributable to the delay in diagnosis, as patients have no symptoms until advanced stages of the disease. More than half of patients have distant metastasis at the time of diagnosis. The most frequent sites of metastasis are the liver, lymph nodes, peritoneum, lung, bone, kidney, and, rarely the skin.Case Report: We report the case of a 45-year-old female patient with adenocarcinoma of the ampulla of Vater metastasizing to the right parietal skull with overlying cutaneous involvement 1 year after a Whipple procedure.Conclusion: Cutaneous and skull metastasis of periampullary neoplasms is unusual, but early recognition of such metastatic disease is important because it indicates a poor prognosis for the patient.