RT Journal Article
SR Electronic
T1 Late Recurrence of Light Chain Deposition Disease after Kidney Transplantation Treated with Bortezomib: A Case Report
JF Ochsner Journal
JO Ochsner J
FD O. P. Jindal Global University
SP 445
OP 449
VO 14
IS 3
A1 Abdul Moiz
A1 Tariq Javed
A1 Jorge Garces
A1 Catherine Staffeld-Coit
A1 Paisit Paueksakon
YR 2014
UL http://www.ochsnerjournal.org/content/14/3/445.abstract
AB Background Light chain deposition disease (LCDD) recurs frequently after renal transplantation with variable presentation.Case Report We report the case of a 67-year-old Caucasian female with recurrence of LCDD after living-donor kidney transplantation. Bone marrow biopsy revealed kappa light chain-restricted population of plasma cells, and the patient met the criteria for multiple myeloma. Her renal function progressively worsened and she became dialysis dependent. She received 1 cycle of bortezomib along with intravenous dexamethasone. She was able to discontinue dialysis within 2 months, and at 1 year follow-up her renal function was stable.Conclusion Bortezomib has a role in the treatment of recurrent LCDD and multiple myeloma in kidney transplant patients. As opposed to traditional regimens, a short course may be beneficial.