TY - JOUR T1 - Role of Special Coagulation Studies for Preoperative Screening of Thrombotic Complications in Simultaneous Pancreas-Kidney Transplantation JF - Ochsner Journal JO - Ochsner J SP - 272 LP - 276 VL - 15 IS - 3 AU - Abdul Moiz AU - Tariq Javed AU - Humberto Bohorquez AU - David S. Bruce AU - Ian C. Carmody AU - Ari J. Cohen AU - Catherine Staffeld-Coit AU - Qingyang Luo AU - George E. Loss, Jr AU - Jorge Garces Y1 - 2015/09/21 UR - http://www.ochsnerjournal.org/content/15/3/272.abstract N2 - Background Vascular thrombosis is a well-known complication after simultaneous pancreas-kidney (SPK) transplantation procedures. The role of preoperative special coagulation studies to screen patients at high risk for vascular thrombosis is unclear and not well studied.Methods This study reports a retrospective medical record review of 83 SPK procedures performed between April 2007 and June 2013 in a single institution. All SPK transplantation recipients underwent preoperative screening for hypercoagulable state.Results Eighteen of 83 patients (21.69%) were diagnosed with vascular thrombosis of the pancreas. Of the 23 patients with at least 1 positive screening test, only 4 had a thrombotic event (17.39%). On the other hand, 14 of 60 patients with negative screening tests developed vascular thrombosis (23.33%). The hypercoagulable screening workup had a positive predictive value of 17.39% and a negative predictive value of 76.67%. The workup also demonstrated low sensitivity (22.22%) and specificity (70.77%).Conclusion No differences were seen in patient or graft survival between groups at 12 months. This retrospective study did not show any benefit of using special coagulation studies to rule out patients at risk for vascular thrombosis after SPK transplantation. ER -