PT  - JOURNAL ARTICLE
AU  - Mark A. Thompson
AU  - Hamang Patel
TI  - Posttransplant Pacemaker Placement: Case Series and Review
DP  - 2010 Dec 21
TA  - Ochsner Journal
PG  - 236--240
VI  - 10
IP  - 4
4099  - http://www.ochsnerjournal.org/content/10/4/236.short
4100  - http://www.ochsnerjournal.org/content/10/4/236.full
SO  - Ochsner J2010 Dec 21; 10
AB  - Introduction: Sinus node dysfunction (SND) following orthotopic heart transplantation may lead to bradycardia, atrioventricular block, sick sinus syndrome, syncope, and death, with 6%-23% of patients requiring pacemakers.Methods: Permanent pacemakers were placed in 5% of orthotopic heart transplants conducted at our institution from January 2002 to October 2008.Results: Three different implant techniques were used over this time: (1) dual-chamber pacing in the donor atrium and ventricle (AD-VD) (62.5%); (2) single lead in the donor atrium (AD) (12.5%); and (3) dual leads placed in both donor and recipient atrium (AR-AD) (25%). Using the percentage of paced histograms recorded in the device, heart rate variability for the types of lead placements were 14% for AD-VD, 35% for AD, and 97% for AR-AD.Discussion: The transplanted heart is characterized physiologically by autonomic denervation and chronotropic incompetence. Restoration of chronotropic competence by atrial pacing increases exercise duration and peak VO2. Rate responsiveness can be achieved in this patient population with the placement of one lead in the remnant right atrium and one lead in the transplanted donor right atrium.