%0 Journal Article %A Christopher P. Zetzmann %A O. Rama Swamy %A George E. Loss, Jr %A Humberto Bohorquez %A Ari J. Cohen %T Improving Donor Livers by Inhibiting TNF-α Production %D 2010 %J Ochsner Journal %P 250-255 %V 10 %N 4 %X Hepatic ischemia/reperfusion (I/R) injury has a significant influence on the outcome of liver transplants. Inhibiting certain enzymatic reactions that occur during I/R injury may have a protective effect on the liver during transplantation. After reviewing the biochemical pathways involved in hepatic I/R injury, we describe a pharmacologic line of defense against this injury by means of the enzyme tissue inhibitor of metalloproteinase 3 (TIMP-3). Current results suggest that TIMP-3 will play a clinically relevant role in improving outcomes of liver transplants by reducing I/R injury to the donor liver. %U https://www.ochsnerjournal.org/content/ochjnl/10/4/250.full.pdf