RT Journal Article
SR Electronic
T1 Early-Onset Bilateral Severe Valvular Regurgitation After Mediastinal Radiotherapy in Hodgkin Lymphoma Survivors: Should We Screen Prior to 10 Years After Mediastinal Radiotherapy?
JF Ochsner Journal
JO Ochsner J
FD O. P. Jindal Global University
DO 10.31486/toj.18.0063
A1 Tushar Mishra
A1 Abdelrahman Ahmed
A1 Mohamed Shokr
A1 Ahmed Rashed
A1 Ahmed S. Yassin
A1 Anupama Kottam
YR 2019
UL http://www.ochsnerjournal.org/content/early/2019/03/20/toj.18.0063.abstract
AB Background: Radiation-induced valvulopathy (RIV) is a common complication of mediastinal radiotherapy and usually occurs at least 10 years after exposure to radiotherapy.Case Report: We report the case of a 37-year-old female with a history of stage IIIB Hodgkin lymphoma who was diagnosed with RIV after all other potential causes of shortness of breath and valvular dysfunction were excluded. The patient's presentation, 6 years after receiving chemotherapy and radiotherapy for Hodgkin lymphoma, was earlier than expected after mediastinal radiotherapy. The patient was started on a regimen of lisinopril, nifedipine, and metoprolol, and her symptoms improved significantly within 4 days of starting medical therapy. We review the literature, discuss the risk factors and determinants of developing RIV, and suggest the ideal timing to screen patients.Conclusion: This case is of educational value for internal medicine, oncology, and cardiology healthcare providers who should consider RIV as a cause of shortness of breath in patients who underwent mediastinal radiotherapy for Hodgkin lymphoma.