Table. Treatments Targeting Specific Pathogenetic Mechanisms of Sickle Cell Disease
Pathogenetic MechanismCounteragent
P-selectin inhibitionCrizanlizumab
PolymerizationVoxelotor
Upregulation of fetal hemoglobin productionHydroxyurea
Butyrate
5-Azacytidine, Decitabine
Oxidative stressL-glutamine
Genetic mutationCRISPR/Cas 9 technology and transplantation
Abnormal rheologyPoloxamer 188
  • CRISPR/Cas 9, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9.