Table 3.

Effect of Inflammation on Interleukin-2 Activity in Phytohemagglutinin (PHA)-Treated Peripheral Blood Mononuclear Cells by Hemoglobin Genotype

Interleukin-2 Activity, IU/mL
HbSS/HbSβ° Genotypes SubgroupHbSC Genotypes Subgroup
WithoutWithWithoutWith
InflammationInflammationInflammationInflammation
PHA Concentration(n=19)(n=13)(n=8)(n=3)
01.37 ± 0.331.64 ± 0.451.39 ± 0.501.29 ± 0.58
55.99 ± 1.184.73 ± 1.136.37 ± 1.993.78 ± 2.66
105.23 ± 1.344.34 ± 0.904.76 ± 1.384.12 ± 2.79
208.82 ± 4.043.74 ± 2.106.82 ± 4.46N/A
  • Notes: Data are presented as means ± standard error of the mean. No significant difference was observed within and between groups of children with and without inflammation.

  • N/A, not available (interleukin-2 data were not available for some of the children).