Table 4.

Correlation Coefficients (r) for Lymphocyte Proliferation (Stimulation Indexes) and Interleukin-2 Activity in Phytohemagglutinin (PHA)-Treated Peripheral Blood Mononuclear Cells and Markers of Nutritional and Hematologic Status in Children With Sickle Cell Disease

Stimulation Indexes by PHAInterleukin-2 (IL-2) Activity by
Concentration (μg/mL), rPHA Concentration (μg/mL), r
Marker2.55101520051020
Weight percentile–0.123–0.116–0.046–0.1160.0300.01870.2150.2540.174
Albumin–0.060–0.127–0.150–0.137–0.174–0.348*–0.169–0.319*–0.588*
Prealbumin0.0770.0350.038–0.027–0.0370.383*0.516*0.456*0.542*
Transferrin–0.022–0.118–0.135–0.132–0.142–0.146–0.2330.086–0.145
Retinol binding protein0.294*0.372*0.357*0.454*0.440*–0.184–0.049–0.0750.264
Hemoglobin0.294*0.222*0.246*0.2210.293*0.022–0.0590.0460.210
White blood cell count–0.160–0.106–0.141–0.087–0.124–0.200–0.268*–0.260*–0.095
  • Notes: Children with the HbSS, HbSβ°, and HbSC genotypes were included in the calculations of correlation coefficients. R values (coefficients) with asterisks are different from zero (P<0.05). Some P values [r] between weight and IL-2 and retinol binding protein and IL-2 that appear as if they should be significant are not significant because of sample size.