Table 2.

Effect of Mild to Moderate Protein-Energy Malnutrition (PEM) on Interleukin-2 Activity in Phytohemagglutinin (PHA)-Treated Peripheral Blood Mononuclear Cells as a Function of Hemoglobin Genotype

Interleukin-2 Activity, IU/mL
GroupWithout PEMWith PEM
GenotypePHA, μg/mLMean ± SEMMedianMean ± SEMMedian
HbSS/HbSβ° subgroup
01.11 ± 0.340.961.59 ± 0.331.15
55.34 ± 1.095.335.41 ± 1.093.95
104.32 ± 1.072.775.11 ± 1.214.13
207.92 ± 5.492.666.19 ± 2.521.48
HbSC subgroup
01.44 ± 0.470.961.00 ± 0.500.43
56.21 ± 1.734.513.78 ± 2.662.11
105.09 ± 1.333.773.53 ± 2.062.04
207.57 ± 4.284.378.47 ± 5.858.48
  • Notes: Data are presented as means ± standard error of the mean. Sample sizes are 13 without PEM vs 20 with PEM and 8 without PEM vs 4 with PEM for the HbSS/HbSβ° and HbSC subgroups, respectively (interleukin-2 activity was not assayed in some of the samples). No significant differences were observed among children with and without PEM or between genotype subgroups.