Table.

Studies of Extracellular Vesicles in Maternal and Fetal Circulation

StudyExtracellular VesicleSample Collection TypeGestational Age, weeksIsolation MethodPregnancyBiological Process Analyzed
Maternal circulationSabapatha et al, 200634ExosomesPlasma28-30Immunomagnetic isolationNormalMaternal immune response
Luo et al, 200935ExosomesPlasma7-11 36-38CentrifugationNormalmiRNA analysis
Sarker et al, 20145ExosomesPlasma6-12Centrifugation and density gradientNormalPlacental exosomes increase from 6-12 weeks
Salomon et al, 201425ExosomesPlasma6-12 22-28 32-36Centrifugation and density gradientNormalExosomes increase across gestation
Pillay et al, 201636ExosomesPlasma>30Centrifugation and density gradientPEHigh levels of placental exosomes in PE
Salomon et al, 20166ExosomesPlasma11-14 22-28 32-36Centrifugation and density gradientGDMHigh levels of placental exosomes in GDM
Ratajczak et al, 201338MicrovesiclesPlasmaN/AN/ANormalAngiogenesis
da Silva Nardi et al, 201637MicrovesiclesPlasma12-18Commercial kitNormalImmunologic role
Goswami et al, 200628STMBPlasma>34CentrifugationPE, IUGRHigh levels of placental STMB
Chen et al, 201239STMBPlasma>34CentrifugationPEHigh levels of placental STMB
Dragovic et al, 201314STMBPlasma>37CentrifugationPEHigh level of EVs in late-onset PE
Moro et al, 201640MicroparticlesPlasma>37CentrifugationHIV infectionImmunologic role
Lok et al, 200841MicroparticlesPlasma12-38CentrifugationPEHigh levels of placental microparticles
Fetal circulationLi et al, 201342MSC-derived exosomesUmbilical vein bloodAt deliveryCentrifugation and filtrationNormalCell therapy
Zhou et al, 201343MSC-derived exosomesUmbilical vein bloodAt deliveryCentrifugation and filtrationNormalCell therapy
Jia et al, 201533MSC-derived exosomesUmbilical vein bloodAt deliveryCentrifugationPEProteomic analysis
  • GDM, gestational diabetes mellitus; HIV, human immunodeficiency virus; IUGR, intrauterine growth restriction; miRNA, micro-RNA; MSC, mesenchymal stem cells; N/A, not applicable; PE, preeclampsia; STMB, syncytiotrophoblast microvesicles.