Abstract
Retinal neovascularization (NV) is a major cause of the blindness associated with such ischemic retinal disorders as diabetic retinopathy, retinopathy of prematurity and retinal occlusion. Neovascularization is induced by complex interactions among growth factors and cytokines. Some studies confirm that VEGF play a central role in neovascularization, there remain some questions as to why VEGF antagonists are only partially effective. Transforming growth factor-β (TGF-β) has been implicated in the development of neovascularization (Gerard et al. 2000). Smad 4 plays the most important role in the TGF-β signal transduction (Zimowska 2006). In this study, we used the model of oxygen-induced retinopathy in neonatal mice to investigate the expression of TGF-β1 and Smad 4 mRNA in the retina, to explore their role in the development of retinal neovascularization.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Behzadian MA, Wang XL, Windsor LJ et al (2001) TGF-beta increases retinal endothelial cell permeability by increasing MMP-9: possible role of glial cells in endothelial barrier function. Invest Ophthalmol Vis Sci 42:853–859
Blobe GC, Schiemann WP, Lodish HF (2000) Role of transforming growth factor b in human disease. N Engl J Med 342:1350–1358
Dong QG, Graziani A, Garlanda C et al (1996) Anti-tumor activity of cytokines against opportunistic vascular tumor in mice. Int J Cancer 65:700–708
Gerard C, William P, Harvey F (2000) Role of transforming growth factor ß in human disease. N Engl J Med 342:1350–1358
Mehra A, Wrana J (2000) TGF – beta and the Smad signal transduction pathway. Biochem Cell Biol 80:605–622
Nagineni CN, Samuel W, Nagineni S et al (2003) Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: involvement of mitogen-activated protein kinases. J Cell Physiol 197:453–462
Orlidge A, D’Amore PA (1987) Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells. J Cell Biol 105:1455–1462
Smith LE, Wesolowski E, McLellan A et al (1994) Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 35:101–111
Wakefield LM, Roberts AB (2002) TGF-b signaling: positive and negative effects on tumorigenesis. Curr Opinion Gen Dev 12:22–29
Yamashita H, Tobari I, Sawa M et al (1997) Functions of the transforming growth factor-beta super family in eyes. Nippon Ganka Gakkai Zasshi 101:927–947
Zhao S, Overbeek PA (2001) Elevated TGFbeta signaling inhibits ocular vascular development. Dev Biol 237:45–53
Zimowska M (2006) Signaling pathways of transforming growth factor beta family members. Postepy Biochem 52(4):360–366
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Yingchuan, F., Chuntao, L., Hui, C., Jianbin, H. (2010). Increased Expression of TGF-β1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice. In: Anderson, R., Hollyfield, J., LaVail, M. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 664. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1399-9_9
Download citation
DOI: https://doi.org/10.1007/978-1-4419-1399-9_9
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-1398-2
Online ISBN: 978-1-4419-1399-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)