Skip to main content

Advertisement

Log in

Skull-base metastases

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Summary

Metastasis to the skull-base particularly affects patients with carcinoma of the breast and prostate. Clinically, the key feature is progressive ipsilateral involvement of cranial nerves. Five syndromes have been described according to the metastatic site including the orbital, parasellar, middle-fossa, jugular foramen and occipital condyle syndromes. Magnetic resonance imaging (MRI) is nowadays the most useful examination to establish the diagnosis but plain films, CT scans with bone windows and isotope bone scans remain helpful to demonstrate bone erosion. Normal imaging studies do not exclude the diagnosis. The treatment depends on the nature of the underlying tumor. Radiotherapy is generally the standard treatment, while some patients with chemosensitive or hormonosensitive lesions benefit from chemotherapy or hormonotherapy and selected patients from surgical removal. Gamma Knife radiosurgery is sometimes a useful alternative, particularly for previously irradiated skull-base regions, and for small tumors (diameter < 30 mm). The overall prognosis is poor, with an overall median survival of about 2.5 years, probably because skull-base metastases appear late in the course of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. HS Greenberg MD Deck B Vikram FC Chu JB Posner (1981) ArticleTitleMetastasis to the base of the skull: clinical findings in 43 patients Neurology 31 530–537 Occurrence Handle6972014

    PubMed  Google Scholar 

  2. AM Stark T Eichmann HM Mehdorrn (2003) ArticleTitleSkull metastases: clinical features, differential diagnosis, and review of the literature Surg Neurol 60 219–225 Occurrence Handle10.1016/S0090-3019(03)00269-6 Occurrence Handle12922038

    Article  PubMed  Google Scholar 

  3. BPW Jansen PAE Sillevis Smitt (2002) Skull and dural metastases D Schiff PY Wen (Eds) Cancer Neurology in Clinical Practice Humana Press Totowa, New Jersey 87–92

    Google Scholar 

  4. A Svare SD Fossa MS Heier (1988) ArticleTitleCranial nerve dysfunction in metastatic cancer of the prostate Br J Urol 61 441–444 Occurrence Handle3395804

    PubMed  Google Scholar 

  5. HJ Yi CH Kim KH Bak JM Kim Y Ko SK Oh (2000) ArticleTitleMetastatic tumors in the sellar and parasellar regions: clinical review of four cases J Korean Med Sci 15 363–365 Occurrence Handle10895984

    PubMed  Google Scholar 

  6. MA Long JE Husband (1999) ArticleTitleFeatures of unusual metastases from prostate cancer Br J Radiol 72 933–941 Occurrence Handle10673942

    PubMed  Google Scholar 

  7. Posner JB: Cancer involving cranial and peripheral nerves. In: Neurologic Complications of Cancer. FA Davis, Philadelphia, 1995, 172–184

  8. SR Gupta DE Zdonczyk A Frank FA. Rubino (1990) ArticleTitleCranial neuropathy in systemic malignancy in a VA population Neurology 40 997–999 Occurrence Handle2345622

    PubMed  Google Scholar 

  9. CE Fadul (1995) Neurological complications of genitourinary cancer RG Wiley (Eds) Neurological Complications of Cancer Marcel Dekker, Inc New York, Inc 382

    Google Scholar 

  10. B Vikram FC Chu (1979) ArticleTitleRadiation therapy for metastases to the base of the skull Radiology 130 465–468 Occurrence Handle104361

    PubMed  Google Scholar 

  11. SI Mubaidin JB Sunna MA Beiruti MM Shennak MS Ayoub (1990) ArticleTitleRenal cell carcinoma presenting as Garcin’s syndrome J Neurol Neurosurg Psychiatry 53 613–614 Occurrence Handle2391528

    PubMed  Google Scholar 

  12. S Harada S Toya Y Iisaka M Ohtani Y Nakamura (1987) ArticleTitleBasal skull metastasis of stomach cancer presenting with Garcin’s syndrome-a case report No Shinkei Geka 15 765–769 Occurrence Handle3670546

    PubMed  Google Scholar 

  13. BY Chang G Cunniffe C Hutchinson (2002) ArticleTitleEnophtalmos associated with primary breast carcinoma Orbit 21 307–310 Occurrence Handle10.1076/orbi.21.4.307.8559 Occurrence Handle12610771

    Article  PubMed  Google Scholar 

  14. O Bairey I Kremer E Rakowsky H Hadar M Shaklai (1994) ArticleTitleOrbital and adnexal involvement in systemic non-hodgkin’s lymphoma Cancer 73 2395–2399 Occurrence Handle8168043

    PubMed  Google Scholar 

  15. R Weisenthal WC Frayer CW Nichols RC Eagle (1988) ArticleTitleBilateral ocular disease as the initial presentation of malignant lymphoma Br J Ophthalmol 72 248–252 Occurrence Handle3288277

    PubMed  Google Scholar 

  16. JE Castaldo JL Bernat FA Meier AR Schned (1983) ArticleTitleIntracranial metastases due to prostate carcinoma Cancer 52 1739–1747 Occurrence Handle6616423

    PubMed  Google Scholar 

  17. DJ Capobianco PW Brazis FA Rubino JN Dalton (2002) ArticleTitleOccipital condyle syndrome Headache 42 142–146 Occurrence Handle10.1046/j.1526-4610.2002.02032.x Occurrence Handle12005291

    Article  PubMed  Google Scholar 

  18. NE Anderson (1995) Neurological complications of breast cancer RG Wiley (Eds) Neurological Complications of Cancer Marcel Dekker Inc New York 313

    Google Scholar 

  19. AP Ferry RL Font (1974) ArticleTitleCarcinoma metastatic to the eye and orbit: I. A clinicopathologic study of 227 cases Arch Ophthalmol 92 276–286 Occurrence Handle4412321

    PubMed  Google Scholar 

  20. HC Boldt JA Nerad (1988) ArticleTitleOrbital metastases from prostate carcinoma Arch Ophthalmol 106 1403–1408 Occurrence Handle3178551

    PubMed  Google Scholar 

  21. J Julien X Ferrer J Drouillard JC Philippe P Desbordes (1984) ArticleTitleCavernous sinus syndrome due to lymphoma J Neurol Neurosurg Psychiatry 47 558–560 Occurrence Handle6547477

    PubMed  Google Scholar 

  22. JL Johnston (2002) ArticleTitleParasellar syndromes Curr Neurol Neurosci Rep 2 423–431 Occurrence Handle12169223

    PubMed  Google Scholar 

  23. RP Mills SJ Insalaco A Joseph (1981) ArticleTitleBilateral cavernous sinus metastasis and ophtalmoplegia J Neurosurg 55 463–466 Occurrence Handle7264738

    PubMed  Google Scholar 

  24. MJD Post DR Mendez LB Kline JD Acker JS Glaser (1985) ArticleTitleMetastatic disease to the cavernous sinus: clinical syndrome and CT diagnosis J Comput Assist Tomogr 9 115–120 Occurrence Handle2981908

    PubMed  Google Scholar 

  25. ML Supler WA Friedman (1992) ArticleTitleAcute bilateral ophtalmoplegia secondary to cavernous sinus metastasis: a case report Neurosurgery 31 783–786 Occurrence Handle1407469

    PubMed  Google Scholar 

  26. G Di Chiro RL Fisher KB Nelson (1964) ArticleTitleThe jugular foramen J Neurosurg 21 447–460 Occurrence Handle14171303

    PubMed  Google Scholar 

  27. HJ Svien HL Baker MH Rivers (1963) ArticleTitleJugular foramen syndrome and allied syndromes Neurology 13 797–809 Occurrence Handle14064314

    PubMed  Google Scholar 

  28. F Graus NE Slatkin (1983) ArticleTitlePapilledema in the metastatic jugular foramen syndrome Arch Neurol 40 816–818 Occurrence Handle6639410

    PubMed  Google Scholar 

  29. A Onishi K Shida (1970) ArticleTitleCase of Collet-Sicard syndrome due to metastasis of prostatic cancer Naika 26 755–757 Occurrence Handle5470882

    PubMed  Google Scholar 

  30. H Nagata S Sato K Tanaka S Ban M Chokyu T Yamamoto M. Ogata (1980) ArticleTitleSkull base metastasis of the breast cancer causing the Collet-Sicard syndrome-a case report No To Shinkei 32 695–700 Occurrence Handle7407020

    PubMed  Google Scholar 

  31. H Satoh T Nishiyama A Horiguchi J Nakashima S Saito M Murai (2000) ArticleTitleA case of Collet-Sicard syndrome caused by skull base metastasis of prostate carcinoma Nippon Hinyokika Gakkai Zasshi 91 562–564 Occurrence Handle10897582

    PubMed  Google Scholar 

  32. H Wilson DH Johnson (1984) ArticleTitleJugular foramen syndrome as a complication of metastatic cancer of the prostate South Med J 77 92–93 Occurrence Handle6695231

    PubMed  Google Scholar 

  33. JR Keane (1996) ArticleTitleTwelfth-nerve palsy: analysis of 100 cases Arch Neurol 53 561–566 Occurrence Handle8660159

    PubMed  Google Scholar 

  34. M Romero C Paradas MD Torrecilla (2000) ArticleTitleIsolated paralysis of the hypoglossal nerve due to metastasis at the base of the cranium Neurologia 15 31 Occurrence Handle10730064

    PubMed  Google Scholar 

  35. O Combarros A Alvarez de Arcaya J Berciano (1998) ArticleTitleIsolated unilateral hypoglossal nerve palsy: nine cases J neurol 245 98–100 Occurrence Handle10.1007/s004150050185 Occurrence Handle9507415

    Article  PubMed  Google Scholar 

  36. M Marco J Dalmau M Aguilar (1989) ArticleTitleTongue paralysis of neoplastic origin Neurologia 4 277–281 Occurrence Handle2637769

    PubMed  Google Scholar 

  37. G Moris C Roig M Misiego A Alvarez J Berciano J Pascual (1998) ArticleTitleThe distinctive headache of the occipital condyle syndrome: a report of four cases Headache 38 308–311 Occurrence Handle10.1046/j.1526-4610.1998.3804308.x Occurrence Handle9595872

    Article  PubMed  Google Scholar 

  38. J Pascual A Gutierrez JM Polo J Berciano (1989) ArticleTitleOccipital condyle syndrome: presentation of a case Neurologia 4 293–295 Occurrence Handle2637770

    PubMed  Google Scholar 

  39. K Pavithran DC Doval S Hukku A Jena (2001) ArticleTitleIsolated hypoglossal nerve palsy due to skull base metastasis from breast cancer Australas Radiol 45 534–535 Occurrence Handle10.1046/j.1440-1673.2001.00977.x Occurrence Handle11903195

    Article  PubMed  Google Scholar 

  40. FT Rotta JG Romano (1997) ArticleTitleSkull base metastases causing acute bilateral hypoglossal nerve palsy J Neurol Sci 148 127–129 Occurrence Handle10.1016/S0022-510X(96)05302-6 Occurrence Handle9125401

    Article  PubMed  Google Scholar 

  41. TH Aung YC Po WK Wong (2002) ArticleTitleHepatocellular carcinoma with metastasis to the skull base, pituitary gland, sphenoid sinus, and cavernous sinus Hong Kong Med J 8 48–51 Occurrence Handle11861994

    PubMed  Google Scholar 

  42. M Kistler HW Pribram (1975) ArticleTitleMetastatic disease of the sella turcica Am J Roentgenol 123 13–21

    Google Scholar 

  43. MB Max MDF Deck DA Rottenberg (1981) ArticleTitlePituitary metastasis: incidence in cancer patients and clinical differentiation from pituitary adenoma Neurology 31 998–1002 Occurrence Handle7196526

    PubMed  Google Scholar 

  44. U Roessmann B Kaufman RL Friede (1970) ArticleTitleMetastatic lesions in the sella turcica and pituitary gland Cancer 25 478–480 Occurrence Handle5413515

    PubMed  Google Scholar 

  45. TM Aaberg SuffixJr M Kay L Sternau (1995) ArticleTitleMetastatic tumors to the pituitary Am J Ophthalmol 119 779–785 Occurrence Handle7785694

    PubMed  Google Scholar 

  46. Grob R, Chantelard JV, Petit T, de Recondo J, Charbonnel B, Dupas, B, Mussini JM, Gayet-Delacroix M, Buthiau D: (Tumeurs malignes sellaires, para-sellaires et de la base du crâne). In : Buthiau D, Khayat D (ed) Scanner et IRM en cancérologie. Springer-Verlag France, Paris: 1995, pp. 75–87

  47. S Telera S Carloia D Cavallotti S Bosco M Manni L Cecconi (2001) ArticleTitleSphenoidal metastasis from prostate carcinoma. Case report and review of the literature Neurochirurgie 47 61–65 Occurrence Handle11283458

    PubMed  Google Scholar 

  48. C Iniguez JA Mauri P Larrode J Perez MA Pina F Morales (1997) ArticleTitleMandibular neuropathy due to infiltration of the Gasser ganglion Rev neurol 25 1092–1094 Occurrence Handle9280644

    PubMed  Google Scholar 

  49. RK Burt WH Sharfman BI Karp WH Wilson (1992) ArticleTitleMental neuropathy (Numb chin syndrome): a harbinger of tumor progression or relapse Cancer 70 877–881 Occurrence Handle1643620

    PubMed  Google Scholar 

  50. JF Seymour MA Rodriguez (1993) ArticleTitleMental neuropathy (numb chin syndrome): a harbinger of tumor progression or relapse. Letter to the editor Cancer 71 874–875

    Google Scholar 

  51. EW Massey J Moore SC Schold (1981) ArticleTitleMental neuropathy from systemic cancer Neurology 31 1277–1281 Occurrence Handle6287347

    PubMed  Google Scholar 

  52. A Lossos T Siegal (1992) ArticleTitleNumb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance Neurology 42 1181–1184 Occurrence Handle1603345

    PubMed  Google Scholar 

  53. JR Calverley AM Mohnac (1963) ArticleTitleSyndrome of the numb chin Arch Intern Med 112 819–821 Occurrence Handle14056846

    PubMed  Google Scholar 

  54. R Reiter M Allert R Knuchel J Strutz (2002) ArticleTitleSinugenic metastasis of bilateral renal cell carcinoma (hypernephroma) HNO 50 165–168 Occurrence Handle10.1007/s001060100546 Occurrence Handle12080628

    Article  PubMed  Google Scholar 

  55. T Kleinjung P Held (2001) ArticleTitleMetastasis in the frontal skull base from hepatocellular carcinoma HNO 49 126–129 Occurrence Handle10.1007/s001060050721 Occurrence Handle11270194

    Article  PubMed  Google Scholar 

  56. LA Loevner DM Yousem (1997) ArticleTitleOverlooked metastatic lesions of the occipital condyle: a missed case treasure trove Radiographics 17 1111–1121 Occurrence Handle9308105

    PubMed  Google Scholar 

  57. VF Chong YF Fan (1998) ArticleTitlePictorial review: radiology of the jugular foramen Clin Radiol 53 405–416 Occurrence Handle9651055

    PubMed  Google Scholar 

  58. J Brillman J Valeriano MH Adatepe (1987) ArticleTitleThe diagnosis of skull base metastases by radionuclide bone scan Cancer 59 1887–1891 Occurrence Handle3567852

    PubMed  Google Scholar 

  59. M Fukumoto Y Osaki D Yoshida Y Ogawa M Fujiwara N Miyazaki A Kurohara N Akagi S Yoshida (1998) ArticleTitleDual-isotope SPECT diagnosis of a skull-base metastasis causing isolated unilateral hypoglossal nerve palsy Ann Nucl Med 12 213–216 Occurrence Handle9795708

    PubMed  Google Scholar 

  60. DW Rowed EE Kassel AJ Lewis (1985) ArticleTitleTransorbital intracavernous needle biopsy in painful ophtalmoplegia J Neurosurg 62 776–780 Occurrence Handle3989599

    PubMed  Google Scholar 

  61. SK Rosahl V Erpenbeck P Vorkapic M Samii (2000) ArticleTitleSolitary follicular thyroid carcinoma of the skull base and its differentiation from ectopic adenoma-review, use of galectin-3 and report of a new case Clin Neurol Neurosurg 102 149–155 Occurrence Handle10.1016/S0303-8467(00)00088-3 Occurrence Handle10996713

    Article  PubMed  Google Scholar 

  62. SM Hall AU Buzdar GR Blumenschein (1983) ArticleTitleCranial nerve palsies in metastatic breast cancer due to osseous metastasis without intracranial involvement Cancer 52 180–184 Occurrence Handle6850542

    PubMed  Google Scholar 

  63. CH Seymore WJ Peeples (1988) ArticleTitleCranial nerve involvement with carcinoma of prostate Urology 31 211–213 Occurrence Handle10.1016/0090-4295(88)90141-0 Occurrence Handle3126588

    Article  PubMed  Google Scholar 

  64. DT Ransom RP Dinapoli RL. Richardson (1990) ArticleTitleCranial nerve lesions due to base of the skull metastases in prostate carcinoma Cancer 65 586–589 Occurrence Handle2297648

    PubMed  Google Scholar 

  65. CE McAvoy S Kamalarajab R Best S Rankin J Bryars K Nelson (2002) ArticleTitleBilateral third and unilateral sixth nerve palsies as early presenting signs of metastatic prostatic carcinoma Eye 16 749–753 Occurrence Handle10.1038/sj.eye.6700210 Occurrence Handle12439671

    Article  PubMed  Google Scholar 

  66. MK Rubinstein (1969) ArticleTitleCranial mononeuropathy as the first sign of intracranial metastases Ann Intern Med 70 49–54 Occurrence Handle4303303

    PubMed  Google Scholar 

  67. DG Payne (1985) ArticleTitleRadiation therapy of tumours involving the skull base Can J Neurol Sci 12 363–365 Occurrence Handle3936612

    PubMed  Google Scholar 

  68. SM Ripa Saldias T Ayuso Blanco E Delpon Perez L Sarria Octavio de Toledo (1994) ArticleTitleInvolvement of cranial pairs as manifestation of prostatic cancer Actas Urol Esp 18 911–914 Occurrence Handle7817864

    PubMed  Google Scholar 

  69. SG Patel B Singh A Polluri PG Bridger G Cantu AD Cheesman GM deSa P Donald D Fliss P Gullane I Janecka SE Kamata LP Kowalski DH Kraus PA Levine LR dos Santos S Pradhan V Schramm C Snyderman WI Wei JP Shah (2003) ArticleTitleCraniofacial surgery for malignant skull base tumors: report of an international collaborative study Cancer 98 1179–1187 Occurrence Handle10.1002/cncr.11630 Occurrence Handle12973841

    Article  PubMed  Google Scholar 

  70. M Sagoh K Kodaki K Ichikizaki K Murakami T Oizumi T Kawase S Toya H Shiga (1996) ArticleTitleSkull base metastasis from renal cell carcinoma presenting as abducens nerve paresis: report of two cases No Shinkei Geka 24 829–833 Occurrence Handle8827733

    PubMed  Google Scholar 

  71. F Gentili WM Lougheed K Yamashiro C Corrado (1985) ArticleTitleMonitoring of sensory evoked potentials during surgery of skull base tumours Can J Neurol Sci 12 336–340 Occurrence Handle4084873

    PubMed  Google Scholar 

  72. G Jia J Zhang Z Wu (1998) ArticleTitleDiagnosis and treatment of skull base metastasis Zhonghua Yi Xue Za Zhi 78 761–762 Occurrence Handle11038829

    PubMed  Google Scholar 

  73. Y Iwai K Yamanaka (1999) ArticleTitleGamma knife radiosurgery for skull base metastasis and invasion Stereotact Funct Neurosurg 72 81–87 Occurrence Handle10.1159/000056443 Occurrence Handle10681695

    Article  PubMed  Google Scholar 

  74. T Tanaka T Kobayashi Y Kida H Oyama M Niwa (1996) ArticleTitleThe results of gamma knife radiosurgery for malignant skull base tumors No Shinkei Geka 24 235–239 Occurrence Handle8851952

    PubMed  Google Scholar 

  75. PC Francel S Bhattacharjee P Tompkins (2002) ArticleTitleSkull base approaches and gamma knife radiosurgery for multimodality treatment of skull base tumors J Neurosurg 97 674–676 Occurrence Handle12507118

    PubMed  Google Scholar 

  76. AJ Cmelak RS Cox JR Adler WE Fee SuffixJr DR Goffinet (1997) ArticleTitleRadiosurgery for skull base malignancies and nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 37 997–1003 Occurrence Handle10.1016/S0360-3016(97)00111-9 Occurrence Handle9169805

    Article  PubMed  Google Scholar 

  77. RC Miller RL Foote RJ Coffey DA Gorman JD Earle PJ Schomberg RW Kline (1997) ArticleTitleThe role of stereotactic radiosurgery in the treatment of malignant skull base tumors Int J Radiat Oncol Biol Phys 39 977–981 Occurrence Handle10.1016/S0360-3016(97)00377-5 Occurrence Handle9392534

    Article  PubMed  Google Scholar 

  78. J Horton ED Means TJ Cunningham KB Olson (1973) ArticleTitleThe numb chin in breast cancer J Neurol Neurosurg Psychiatry 36 211–216 Occurrence Handle4708456

    PubMed  Google Scholar 

  79. R Unsold AB Safran E Safran WF Hoyt (1980) ArticleTitleMetastatic infiltration of nerves in the cavernous sinus Arch Neurol 37 59–61 Occurrence Handle7350906

    PubMed  Google Scholar 

  80. PD Thompson RJS Wise BE Kendall (1985) ArticleTitleEnopthalmos and metastatic carcinoma of the breast. Letter to the editor J Neurol Neurosurg Psychiatry 48 1305–1306 Occurrence Handle4087010

    PubMed  Google Scholar 

  81. DG Potts RD Zimmerman (1985) ArticleTitleNuclear magnetic resonance imaging of skull base lesions Can J Neurol Sci 12 327–331 Occurrence Handle4084871

    PubMed  Google Scholar 

  82. RA Patchell JB Posner (1986) ArticleTitleNeurologic complications of carcinoid Neurology 36 745–749 Occurrence Handle3703281

    PubMed  Google Scholar 

  83. JP Shah N Sundaresan J Galicich EW Strong (1987) ArticleTitleCraniofacial resection for tumors involving the base of the skull Am J Surg 154 352–358 Occurrence Handle10.1016/0002-9610(89)90003-2 Occurrence Handle3661836

    Article  PubMed  Google Scholar 

  84. O Hirai H Kikuchi N Hashimoto (1992) ArticleTitleSkull base metastasis from gastric cancer-case report Neurol Med Chir (Tokyo) 32 908–910

    Google Scholar 

  85. JE O’Boyle TA Gardner A Oliva RW Enzenauer (1992) ArticleTitleSixth nerve palsy as the initial presenting sign of metastatic prostate cancer. A case report and review of the literature J Clin Neuroophtalmol 12 149–153

    Google Scholar 

  86. S Rajaratnam MS Seshadri A Nair N Shanthly V Srivastava (2000) ArticleTitlePheochromocytoma with base of skull metastasis J Assoc Physicians India 48 850–851 Occurrence Handle11273489

    PubMed  Google Scholar 

  87. K Endo R Okano Y Kuroda S Yamada K Tabei (2001) ArticleTitleRenal cell carcinoma with skull base metastasis preceded by paraneoplastic signs in a chronic hemodialysis patient Intern Med 40 924–930 Occurrence Handle11579958

    PubMed  Google Scholar 

  88. Y Liel G Zucker S Lantsberg S Argov HJ Zirkin (2002) ArticleTitleMalignant pheochromocytoma simulating meningioma: coexistence of recurrent meningioma and metastatic pheochromocytoma in the base of the skull Isr Med Assoc 4 829–831

    Google Scholar 

  89. LM Buono A Silberschmidt R Foroozan PJ. Savino (2002) ArticleTitleMetastatic synovial sarcoma to the skull base and orbit Am J Ophtalmol 134 785–787 Occurrence Handle10.1016/S0002-9394(02)01657-4

    Article  Google Scholar 

  90. G Alessi M Lemmerling L Vereecken L De Waele (2003) ArticleTitleBenign metastasising leiomyoma to skull base and spine: a report of two cases Clin Neurol Neurosurg 105 170–174 Occurrence Handle10.1016/S0303-8467(03)00002-7 Occurrence Handle12860509

    Article  PubMed  Google Scholar 

  91. ML Alvarez Suarez M Alvarez-Buylla Camino JJ Barbon Garcia G Moris De La Tassa L Pastor Hernandez (2003) ArticleTitlePainful ophtalmoplegia secondary to larynx carcinoma Arch Soc Esp Oftalmol 78 43–46 Occurrence Handle12571774

    PubMed  Google Scholar 

  92. E Franco E Gil-Neciga G Cano R Espinosa R Ruiz-Mateos M Ollero (1999) ArticleTitleSphenoid metastasis mimicking a meningioma as the initial feature of adenocarcinoma of the prostate Rev Neurol 29 929–932 Occurrence Handle10637842

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jean-Yves Delattre.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Laigle-Donadey, F., Taillibert, S., Martin-Duverneuil, N. et al. Skull-base metastases. J Neurooncol 75, 63–69 (2005). https://doi.org/10.1007/s11060-004-8099-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-004-8099-0

Keywords

Navigation