Skip to main content

Advertisement

Log in

Occipital Neuralgia

  • Uncommon Headache Syndromes (J Ailani, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Occipital pain is a common complaint amongst patients with headache, and the differential can include many primary headache disorders such as cervicogenic headache or migraine. Occipital neuralgia is an uncommon cause of occipital pain characterized by paroxysmal lancinating pain in the distribution of the greater, lesser or third occipital nerves. Greater occipital nerve blockade with anesthetics and/or corticosteroids can aid in confirming the diagnosis and providing pain relief. However, nerve blocks are also effective in migraine headache and misdiagnosis can result in a false positive. Physical therapy and preventive medication with antiepileptics and tricyclic antidepressants are often effective treatments for occipital neuralgia. Refractory cases may require intervention with pulsed radiofrequency or occipital nerve stimulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Headache Classification Committee of the International Headache Society: International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013, 33:629–808. This recently published update of the ICHD includes more specific diagnostic criteria for occipital neuralgia. The previous ICHD-2 only included tenderness over the affected area, whereas current criteria also require the presence of dysesthesia or allodynia. The update also removed mention of persistent aching between paroxysms.

  2. Kelman L. Pain characteristics of the acute migraine attack. Headache. 2006;46:942–53.

    Article  PubMed  Google Scholar 

  3. Afridi SK, Shields KG, Bhola R, Goadsby PJ. Greater occipital nerve injection in primary headache syndromes: prolonged effects from a single injection. Pain. 2006;122:126–9.

    Article  CAS  PubMed  Google Scholar 

  4. Ashkenazi A, Young WB. The effects of greater occipital nerve block and trigger point injection on brush allodynia and pain in migraine. Headache. 2005;45:350–4.

    Article  PubMed  Google Scholar 

  5. Caputi CA, Firetto V. Therapeutic blockade of greater occipital and supraorbital nerves in migraine patients. Headache. 1997;37:174–9.

    Article  CAS  PubMed  Google Scholar 

  6. Gale GD, Caputi CA, Firetto V. Therapeutic blockade of the greater occipital and supraorbital nerves in migraine patients. Headache. 1998;38:57.

    CAS  PubMed  Google Scholar 

  7. Guvencer M, Akyer P, Sayhan S, Tetik S. The importance of the greater occipital nerve in the occipital and suboccipital region for nerve blockade and surgical approaches- an anatomical study on cadavers. Clin Neurol Neurosurg. 2011;113:289–94.

    Article  PubMed  Google Scholar 

  8. Lang J. Musculature. In: Clinical anatomy of the cervical spine. New York: Thieme Medical Publishers; 1993, p. 127.

  9. Magnusson T, Ragnarsson T, Bjornsson A: Occipital nerve release in patients with whiplash trauma and occipital neuralgia. Headache 1996, 36:32–6.

    Google Scholar 

  10. Loukas M, El-Sedfy A, Tubbs RS, et al. Identification of greater occipital nerve landmarks for the treatment of occipital neuralgia. Folia Morphol (Warsz). 2006;65:337–42.

    CAS  Google Scholar 

  11. Cho JC, Haun DW, Kettner NW. Sonographic evaluation of the greater occipital nerve in unilateral occipital neuralgia. J Ultrasound Med. 2012;31:37–42. This study utilizes ultrasound to evaluate changes in the cross sectional area and circumference of symptomatic occipital nerves in patients with unilateral occipital neuralgia. Similar changes have been seen in other peripheral neuropathies caused by entrapment.

    PubMed  Google Scholar 

  12. White JB, Atkinson PP, Cloft HJ, Atkinson JL. Vascular compression as a potential cause of occipital neuralgia: a case report. Cephalalgia. 2008;28:78.

    CAS  PubMed  Google Scholar 

  13. Hashiguchi A, Mimata C, Ichimura H, et al. Occipital neuralgia as a presenting symptom of cervicomedullary dural arteriovenous fistula. Headache. 2007;47:1095–7.

    Article  PubMed  Google Scholar 

  14. Cerrato P, Bergui M, Imperiale D, et al. Occipital neuralgia as isolated symptom of an upper cervical cavernous angioma. J Neurol. 2002;249:1464–5.

    Article  PubMed  Google Scholar 

  15. De Santi L, Monti L, Menci E, et al. Clinical-radiologic heterogeneity of occipital neuralgiform pains as multiple sclerosis relapse. Headache. 2009;49:304–7.

    Article  PubMed  Google Scholar 

  16. Boes C. C2 myelitis presenting with neuralgiform occipital pain. Neurology. 2005;64:1093–4.

    Article  PubMed  Google Scholar 

  17. Nikakis P, Koustis G, Potagas C, et al. Occipital neuralgia as an isolated symptom of C2 myelitis. Headache. 2006;46:1304–6.

    Article  PubMed  Google Scholar 

  18. Smith DL, Lucas LM, Kumar KL. Greater occipital neuralgia: an unusual presenting feature of neurosyphilis. Headache. 1987;27:552–4.

    Article  CAS  PubMed  Google Scholar 

  19. Hammond SR, Danta G. Occipital neuralgia. Clin Exp Neurol. 1978;15:258–70.

    CAS  PubMed  Google Scholar 

  20. Young WB, Silberstein SD, Nahas SJ, Marmura MJ. Jefferson headache manual. New York: Demos; 2011. p. 190.

    Google Scholar 

  21. Lefkowitz DS. Approach to the patient with chronic and recurrent headache. In: Biller J, editor. Practical neurology. 3rd ed. Philadelphia: Williams & Wilkins; 2008. p. 257.

    Google Scholar 

  22. Kuhn WF, Kuhn SC, Gilberstadt H. Occipital neuralgias: clinical recognition of a complicated headache. A case series and literature review. J Orofac Pain. 1997;11:158–65.

    CAS  PubMed  Google Scholar 

  23. Newman LC, Levin M. Headache and facial pain. New York: Oxford University Press; 2008. p. 108–12.

    Book  Google Scholar 

  24. Ashkenazi A, Levin M. Greater occipital nerve block for migraine and other headaches: is it useful? Curr Pain Headache Rep. 2007;11:231–5.

    Article  PubMed  Google Scholar 

  25. Pfadenhauer K, Weber H. Giant cell arteritis of the occipital arteries-a prospective color coded duplex sonography study in 78 patients. J Neurol. 2003;250:844–9.

    Article  PubMed  Google Scholar 

  26. Jundt JW, Mock D. Temporal arteritis with normal erythrocyte sediment rates presenting as occipital neuralgia. Arthritis Rhem. 1991;34:217–9.

    Article  CAS  Google Scholar 

  27. Bogduk N. The neck and headaches. Neurol Clin N Am. 2004;22:151–71.

    Article  Google Scholar 

  28. Vanelderen P, Lataster A, Levy R, et al. Occipital neuralgia. Pain Pract. 2010;10:137–44.

    Article  PubMed  Google Scholar 

  29. Anthony M. Headache and the greater occipital nerve. Clin Neurol Neurosurg. 1992;94:297–301.

    Article  CAS  PubMed  Google Scholar 

  30. Levin M. Nerve blocks and nerve stimulator in headache disorders. Tech Reg Anesth Pain Manag. 2009;13:42–9.

    Article  Google Scholar 

  31. Ward JB. Greater occipital nerve block. Semin Neurol. 2003;23:59–61.

    Article  PubMed  Google Scholar 

  32. Ashkenazi A, Matro R, Shaw JW, et al. Greater occipital nerve block using local anaesthetics alone or with triamcinolone for transformed migraine: a randomized comparative study. J Neurol Neurosurg Psychiatry. 2008;79:415–7.

    Article  CAS  PubMed  Google Scholar 

  33. Shields KG, Levy MJ, Goadsby PJ. Alopecia and cutaneous atrophy after greater occipital nerve infiltration with corticosteroid. Neurology. 2004;63:2193–4.

    Article  CAS  PubMed  Google Scholar 

  34. Okuda Y, Matsumoto T, Shinohara M, et al. Sudden unconsciousness during a lesser occipital nerve block in a patient with the occipital bone defect. Eur J Anaesthesiol. 2001;18:829–32.

    Article  CAS  PubMed  Google Scholar 

  35. Goadsby PJ, Zagami AS. Stimulation of the superior sagittal sinus increases metabolic activity and blood flow in certain regions of the brainstem and upper cervical spinal cord of the cat. Brain. 1991;114:1001–11.

    Article  PubMed  Google Scholar 

  36. Goadsby PJ, Hoskin KL, Knight YE. Stimulation of the greater occipital nerve increases metabolic activity in the trigeminal nucleus caudalis and cervical dorsal horn of the cat. Pain. 1997;73:23–8.

    Article  CAS  PubMed  Google Scholar 

  37. Navani A, Mahajan G, Kreis P, et al. A case of pulsed radiofrequency lesioning for occipital neuralgia. Pain Med. 2006;7:453–6.

    Article  PubMed  Google Scholar 

  38. Chua NH, Vissers KC, Sluijter ME. Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications- a review. Acta Neurochir (Wien). 2011;153:763–71.

    Article  Google Scholar 

  39. Vanelderen P, Rouwette T, De Vooght P, et al. Pulsed radiofrequency for the treatment of occipital neuralgia: a prospective study with six months of follow-up. Reg Anesth Pain Med. 2010;35:148–51.

    Article  PubMed  Google Scholar 

  40. Huang JHY, Galvagno SM, Hameed M, et al. Occipital nerve pulsed radiofrequency treatment: a multi-center study evaluating predictors of outcome. Pain Med. 2012;13:489–97.

    Article  PubMed  Google Scholar 

  41. Weiner RL, Reed KL. Peripheral neurostimulation for control of intractable occipital neuralgia. Neuromodulation. 1999;2:217–21.

    Article  CAS  PubMed  Google Scholar 

  42. Slavin KV, Nersesyan H, Wess C. Peripheral neurostimulation for treatment of intractable occipital neuralgia. Neurosurgery. 2006;58:112–8.

    Article  PubMed  Google Scholar 

  43. Johnston CS, Sundaraj R. Occipital nerve stimulation for the treatment of occipital neuralgia-eight case studies. Neuromodulation. 2006;9:41–7.

    Article  Google Scholar 

  44. Melvin EA, Jordan ER, Weiner RL, Primm D. Using peripheral nerve stimulation to reduce the pain of c2-mediated headaches: a preliminary report. Pain Phys. 2007;10:453–60.

    Google Scholar 

  45. Shaladi A, Crestani F, Saltari R, Piva B. Percutaneous electrical nerve stimulation of peripheral nerve for the intractable occipital neuralgia. Recenti Prog Med. 2008;99:295–301.

    PubMed  Google Scholar 

  46. Magown P, Garcia R, Beauprie I, Mendez IM. Occipital nerve stimulation for intractable occipital neuralgia: an open surgical technique. Clin Neurosurg. 2009;56:119–24.

    PubMed  Google Scholar 

  47. Kapural L, Stillman M, Kapural M, et al. Botulinum toxin occipital nerve block for the treatment of sever occipital neuralgia: a case series. Pain Pract. 2007;7:337–40.

    Article  PubMed  Google Scholar 

  48. Taylor M, Silva S, Cottrell C. Botulinum toxin type-a (botox) in the treatment of occipital neuralgia: a pilot study. Headache. 2008;48:1476–81.

    Article  PubMed  Google Scholar 

Download references

Compliance with Ethics Guidelines

Conflict of Interest

Dr. Carrie Dougherty declares no potential conflicts of interest relevant to this article.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carrie Dougherty.

Additional information

This article is part of the Topical Collection on Uncommon Headache Syndromes

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dougherty, C. Occipital Neuralgia. Curr Pain Headache Rep 18, 411 (2014). https://doi.org/10.1007/s11916-014-0411-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11916-014-0411-x

Keywords

Navigation