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Lung Transplant Rejection and Surveillance in 2016: Newer Options

  • Thoracic Transplantation (J Kobashigawa, Section Editor)
  • Published:
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Abstract

Lung allograft rejection is a major risk factor for the development of chronic lung allograft dysfunction. It is a significant cause of morbidity and mortality, and limits survival post lung transplantation, which is lower than any other solid organ transplant. The invasive nature of current methods of diagnosis which consists of histological diagnosis via transbronchial biopsy and the lack of sensitivity of clinical surveillance warrants the search for novel less invasive and more accurate methods of diagnosis. This review aims to highlight recent changes to current methods of surveillance and diagnosis as well as present some of the novel methods that are becoming available.

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Conflict of Interest

Mark Benzimra and Allan Glanville declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Thoracic Transplantation

Glossary

ACR

Acute cellular rejection

AMR

Antibody-mediated rejection

BALF

Bronchoalveolar lavage fluid

BOS

Bronchiolitis obliterans syndrome

CLAD

Chronic lung allograft dysfunction

Col-V

Collagen V

DSA

Donor specific HLA antibodies

HLA

Human leucocyte antigen

Kα1T

K-alpha-1 tubulin

LTX

Lung transplantation

MFI

Mean fluorescence intensity

miRNA

Micro-ribonucleic acid

OB

Obliterative bronchiolitis

RCLAD

Restrictive chronic lung allograft dysfunction

SAB

Single-antigen beads

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Benzimra, M., Glanville, A.R. Lung Transplant Rejection and Surveillance in 2016: Newer Options. Curr Transpl Rep 3, 192–198 (2016). https://doi.org/10.1007/s40472-016-0104-y

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