Clinical studyElectrophysiologic studies in the denervated transplanted human heart: II. Response to norepinephrine, isoproterenol and propranolol☆
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2016, American Journal of Emergency MedicineCitation Excerpt :Cardiac dysrhythmia is common following transplant, especially the early postoperative period, because of sinoatrial and atrioventricular node damage, ischemia, rejection, and accelerated atherosclerosis [132-134]. The denervated heart possesses increased sensitivity to sympathomimetic agents, intrinsic and extrinsic [132-134]. Common dysrhythmias include bradycardia, atrial flutter and fibrillation, atrioventricular block, and ventricular ectopy [135-138].
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2015, BiomaterialsCitation Excerpt :Norepinephrine showed a significant increase in frequency and force which correlated with in vivo inotropic action. In humans, intravenous administration of norepinephrine led to an increase of 32% in the ventricular contractile force in 15 patients [41] and an increase of 32 beats/min in the rate of the donor atrium in patients who had received a transplanted human heart [42]. Sotalol, a Class III antiarrhythmic, prolongs the atrial and ventricular monophasic action potential.
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This work was supported in part by Grants HL-5866, HL-13108, HL-08696, and Program Project Grant NIH 1-PO1-HL-15833 from the National Institutes of Health, Bethesda, Md.
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Present address: Yale New Haven Hospital, 333 Cedar St., New Haven, Conn. 06510.