Cell
Volume 65, Issue 4, 17 May 1991, Pages 691-699
Journal home page for Cell

Article
Human D-type cyclin

https://doi.org/10.1016/0092-8674(91)90100-DGet rights and content

Abstract

A cDNA library prepared from a human glioblastoma cell line has been introduced into a budding yeast strain that lacks CLN1 and CLN2 and is conditionally deficient for CLN3 function. We rescued a gene that we call cyclin D1. It is related to A-, B-, and CLN-type cyclins, but appears to define a new subclass within the cyclin gene family. Transcription of the cyclin D1 gene gives rise to two major transcripts through alternative polyadenylation. The cyclin D1 gene transcript and its 34 kd product are both abundant in the glioblastoma cell line of origin.

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