ViewpointSusceptibility to type I diabetes: HLA-DQ and DR revisited☆
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Cited by (308)
Differences in promoter DNA methylation and mRNA expression of individual alleles of the HLA class II DQA1 gene
2015, Immunology LettersCitation Excerpt :In this way, we could speculate that presentation of high concentrations of peptide-MHC complexes with high affinity to TCR leads to preferential induction of pro-inflammatory Th17 cells [29] and suboptimal number of tolerogenic Foxp3+ cells [28]. By far the most expressed DQA1 alleles, DQA1*03, are associated with multiple autoimmune diseases [30–32] and it would be interesting to see whether their high expression level indeed is one of the factors that favor breaking of immune tolerance in their carriers. Transcription of all HLA class II genes is regulated very tightly and in a coordinated fashion by common class II transactivator, CIITA [1,33].
Family-based association study of HLA class II with type 1 diabetes in Moroccans
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This work was supported by the Juvenile Diabetes Foundation (grants JDF193182 and JDF195094) and the National Institutes of Health (grant HL47138).