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Susceptibility to type I diabetes: HLA-DQ and DR revisited

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Abstract

The HLA class II region encodes the strongest genetic contribution to insulin-dependent diabetes mellitus (IDDM); however, the complex HLA associations with IDDM are not yet fully understood. Here, Jin-Xiong She argues that all DR and DQ molecules in an individual act in concert to determine the overall HLA-encoded susceptibility to IDDM and that apparent inter-racial discrepancies of HLA associations can be explained by DR-DQ linkage disequilibrium or by DQ αβ trans-complementation.

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    This work was supported by the Juvenile Diabetes Foundation (grants JDF193182 and JDF195094) and the National Institutes of Health (grant HL47138).

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