Brief reportAdverse systemic effects from pledgets of topical ocular phenylephrine 10%☆
References (5)
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Possible adverse effects from topical ocular 10% phenylephrine
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Cited by (55)
The safety of intracameral phenylephrine – A systematic review
2022, Survey of OphthalmologyCitation Excerpt :Shams, Jafari, and Mansfield reported a case of ventricular fibrillation in a patient undergoing cataract surgery when using a 2.5% solution of intracameral phenylephrine.38 Although there are numerous case reports of cardiovascular complications when using 10% topical phenylephrine in ophthalmic procedures in the literature,3,14,21 to our knowledge, no further instances of systemic complications associated with intracameral phenylephrine have been reported. Fraunfelder and Scafidi reviewed the complications after using 10% phenylephrine formulation topically and reported 15 cases of myocardial infarction and 11 deaths.13
Ocular Drug Delivery and Toxicology
2020, Drug-Induced Ocular Side Effects, Eigtht EditionCardiac, Vascular, and Renal Drugs
2020, Drug-Induced Ocular Side Effects, Eigtht EditionAnesthesia for Ophthalmic Surgery
2016, Smith's Anesthesia for Infants and Children, Ninth EditionOur own worst enemy: Pharmacologic mechanisms of hypertension
2015, Advances in Chronic Kidney DiseaseCitation Excerpt :It is available as an oral, nasal, or ophthalmic decongestant over-the-counter, an injectable vasopressor for shock or hypotension, and an eye drop for mydriasis in ophthalmologic procedures. There have been case reports of hypertension, myocardial infarctions, cerebrovascular accident, subarachnoid hemorrhages, and even cardiac arrest because of the use of topical phenylephrine 10% for ocular surgeries.46,47 At least one of these cases could be attributed to an inadvertent overdose; however, increases in blood pressure have been reported in up to 2% of patients who received topical phenylephrine 10%.46
Intracerebral hemorrhage associated with oral phenylephrine use: A case report and review of the literature
2014, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Weisberg15 reported a case of ICH 30 minutes following PHE topical administration (1 drop of 2.5% in each eye). Systemic effects of topical ocular PHE (10%) have been reported to include severe hypertension, “cerebrovascular accident”, severe headache, tonic convulsion, and SAH among others (cardiac arrhythmias/arrest) and can occur after a single exposure within minutes.20 One case of stroke after intracorporeal injection was also reported.
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Supported in part by an unrestricted grant from Research to Prevent Blindness, New York, New York.