Original articleMineral homeostasis and bone mass in children treated for acute lymphoblastic leukemia
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Cited by (88)
Systematic review and meta-analysis: Prevalence and possible causes of vitamin D deficiency and insufficiency in pediatric cancer patients
2016, Clinical NutritionCitation Excerpt :PTH measured alongside vitamin D is considered a more sensitive physiological measure of vitamin D status in the healthy population [6]; therefore this was also assessed. Twelve out of 19 studies [22–27,30–33,35,38] investigated plasma PTH levels as well as 25(OH)D or 1,25(OH)D (Table 1). However, only 5 studies reported plasma PTH in relation to either 25(OH)D or 1,25(OH)D with very heterogeneous findings: (i) Bilariki et al. (2010) [24] reported hyperparathyroidism in half of patients (n = 15) who were 25(OH)D deficient (n = 32); (ii) Atkinson et al. (1989) [31] reported normal plasma PTH and 25(OH)D in all ALL patients; (iii) Halton et al. (1996) [27] stated that 9 children with low 1,25(OH)D had also developed hyperparathyroidism; (iv) Schepper et al. (1994) [35] found normal plasma 1,25(OH)D levels, however 15% (2/13) of these had hyperparathyroidism and 8% (1/13) hypoparathyroidism; (v) Finally, Sinha et al. (2011) [38] did not establish any significant associations between plasma 25(OH)D and PTH levels in pediatric cancer patients (r = 0.07; p = 0.65); but this association was significant in the control group (r = −0.42; p < 0.01).
Bone health in patients with brain tumors
2007, Surgical NeurologyCitation Excerpt :To our knowledge, no data have been published about bone loss related to chemotherapic drugs commonly used in brain tumor treatment such as nitrosoureas (BCNU, CCNU) or temozolomide. There are reports of increased incidence of fractures among children after use of MTX for leukemia, although many of these children probably received GCs as well [3]. The mechanism of action of MTX on bone at a cellular level remains unclear, although MTX affects bone cell mechanotransduction by interfering with integrin-mediated signaling [25].
Bone morbidity in pediatric acute lymphoblastic leukemia
2020, Annals of Pediatric Endocrinology and MetabolismBone mineral density, lean body mass and bone biomarkers following physical exercise in children with acute lymphoblastic leukemia undergoing chemotherapy
2018, Iranian Journal of Blood and Cancer
- 1
Dr Atkinson is a Career Scientist of the Ministry of Health of Ontario
- 2
Dr. Fraher is a National Institute of Nutrition (Canada) University Scholar.