Elsevier

The Lancet

Volume 358, Issue 9297, 8 December 2001, Pages 1964-1965
The Lancet

Research Letters
Airway function in infants newly diagnosed with cystic fibrosis

https://doi.org/10.1016/S0140-6736(01)06970-7Get rights and content

Summary

The lung function of infants with cystic fibrosis is often reduced shortly after diagnosis. We measured the airway function of newly diagnosed infants to test whether this reduction is independent of clinically recognised lower respiratory illness. We compared the airway function of 33 infants with cystic fibrosis and 87 healthy controls after adjustment for sex, age, body weight and length, and exposure to maternal smoking. Airway function was significantly reduced in children with cystic fibrosis, even in those without clinically recognised previous lower respiratory illness. Our findings raise important questions about the onset and natural history of impaired airway function in infants with cystic fibrosis.

References (5)

  • TZ Khan et al.

    Early pulmonary inflammation in infants with cystic fibrosis

    Am J Respir Crit Care Med

    (1995)
  • M Gappa et al.

    Lung function testing in infants with cystic fibrosis: lessons from the past and future directions

    Pediatr Pulmonol

    (2001)
There are more references available in the full text version of this article.

Cited by (111)

  • Variability of lung clearance index in clinically stable cystic fibrosis lung disease in school age children

    2018, Journal of Cystic Fibrosis
    Citation Excerpt :

    MBW offers a non-invasive tool with good feasibility across all ages to detect early lung disease changes, and is of great interest to the paediatric CF community [4]. There are increasing evidence that in CF pulmonary deterioration starts early in life and can occur in the absence of respiratory symptoms [5,6]. Frequent pulmonary exacerbations (PEx) are associated with impaired quality of life, accelerated decline in pulmonary function and premature death [7,8].

  • Monitoring early stage lung disease in cystic fibrosis

    2020, Current Opinion in Pulmonary Medicine
View all citing articles on Scopus
View full text