Trends in Cell Biology
Volume 5, Issue 12, December 1995, Pages 448-450
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Functions of pRb and p53: what's the connection?

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Abstract

The pRb and p53 proteins have tumour suppressor functions and both are regulators of transcription. Their mechanisms of transcriptional regulation are unrelated in many ways - in contrast, it would appear, to their biological functions. This review highlights their biological connections in the light of recent advances in understanding the mechanisms of pRb and p53 function.

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