American Journal of Obstetrics and Gynecology
ResearchGynecologyCharacterization of the host inflammatory response following implantation of prolapse mesh in rhesus macaque
Section snippets
Meshes
The test articles consisted of 3 polypropylene meshes with varying textile and mechanical characteristics as previously described.12, 26 Briefly, specific weight and pore size were provided by the manufacturer. Porosity was determined using a custom-designed algorithm (Matlab, Version 8.0; Mathworks, Natick, MA) and stiffness was determined by ball burst testing. Table 1 shows the relevant mechanical and structural characteristics associated with each mesh. Of note, UltraPro is manufactured
Results
Animals had similar age, parity, and pelvic organ prolapse quantification (POP-Q) stage (Table 2). The POP-Q staging methods utilized were the same as that utilized in human beings adjusted to account for the shorter length of the macaque vagina.29 Animals in the Restorelle group weighed more than the other groups (P = .042); however, weight did not correlate with any of the measured outcomes (P > .36 for all). One animal in the study demonstrated a mesh exposure into the vagina. There were no
Comment
The present study sought to define the host inflammatory response to 3 polypropylene meshes with distinct textile properties following implantation via sacrocolpopexy in the rhesus macaque. The most significant findings were that, while all mesh materials elicited a predominantly M1 macrophage profile, lower-weight, higher-porosity meshes (UltraPro and Restorelle) elicited a shift in the M2/M1 macrophage ratio in the area around individual mesh fibers. The concentration of antiinflammatory
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This work was supported by National Institutes of Health awards R01 HD061811 (P.A.M.) and K12HD043441 (B.N.B.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding source had no involvement in the study design, collection of data, analysis of data, interpretation of data, writing of the report, or the decision to submit for publication.
The authors report no conflict of interest.
Cite this article as: Brown BN, Mani D, Nolfi AL, et al. Characterization of the host inflammatory response following implantation of prolapse mesh in rhesus macaque. Am J Obstet Gynecol 2015;213:668.e1-10.