Elsevier

Heart Rhythm

Volume 5, Issue 3, March 2008, Pages 498-499
Heart Rhythm

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Calcium channel blocker and adenosine triphosphate terminate bidirectional ventricular tachycardia in a patient with Andersen-Tawil syndrome

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Cited by (20)

  • Bidirectional ventricular tachycardia in ischemic cardiomyopathy during ablation

    2017, HeartRhythm Case Reports
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    Bidirectional VT (BVT) is a form of VT with a beat-to-beat alteration in the QRS axis on the surface ECG. It is uncommon and usually associated with certain specific conditions, such as CPVT,2 digoxin toxicity, and long QT syndrome type 7 (Andersen-Tawil syndrome).3 It had also been rarely reported in subjects with sarcoidosis4 and acute coronary syndrome (ACS).5

  • Andersen-Tawil syndrome: Clinical presentation and predictors of symptomatic arrhythmias – Possible role of polymorphisms K897T in KCNH2 and H558R in SCN5A gene

    2017, Journal of Cardiology
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    There are only few studies suggesting influence of flecainide on cardiac arrhythmias reduction but benefit of flecainide for prevention of medically significant cardiac arrhythmias is still unknown. Moreover, it is known that this drug causes many side effects often making treatment impossible [9,10]. A carrier could present only a part of the triad or even be asymptomatic [11].

  • Imipramine for incessant ventricular arrhythmias in 2 unrelated patients with Andersen-Tawil syndrome

    2015, Heart Rhythm
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    β-Blockers have no effect as pointed out by most reports.8 Erdogan et al,15 Sumitomo et al,16 and Kannankeril et al17 have all reported using verapamil to control complex VT in patients with ATS. In those reports, frequent ectopy continued despite the decrease in runs of VT.

  • Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations

    2015, Heart Rhythm
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    Bokenkamp et al13 reported that β-blockers, the mainstay for other types of long QT syndrome, are ineffective for the suppression of VAs in patients with ATS. Similarly, the efficacy of calcium channel blockers is uncertain; in addition, calcium channel blockers have risk of torsades de pointes and syncope in patients with ATS.10,11,13 In this study, although β-blockers and/or calcium channel blockers were administered in 6 patients to prevent VAs, these drugs could not suppress VAs.

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Dr. Shimizu was supported by health sciences research grants (H18-Research on Human Genome-002) from the Ministry of Health, Labour and Welfare, Japan.

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