ImageCalcium channel blocker and adenosine triphosphate terminate bidirectional ventricular tachycardia in a patient with Andersen-Tawil syndrome
References (5)
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Cellular basis for electrocardiographic and arrhythmic manifestation of Andersen-Tawil syndrome (LQT7)
Heart Rhythm
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Electrophysiologic characteristics of an Andersen syndrome patient with KCNJ2 mutation
Heart Rhythm
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Cited by (20)
Efficacy of flecainide in bidirectional ventricular tachycardia and tachycardia-induced cardiomyopathy with Andersen-Tawil syndrome
2022, European Journal of Medical GeneticsBidirectional ventricular tachycardia in ischemic cardiomyopathy during ablation
2017, HeartRhythm Case ReportsCitation Excerpt :Bidirectional VT (BVT) is a form of VT with a beat-to-beat alteration in the QRS axis on the surface ECG. It is uncommon and usually associated with certain specific conditions, such as CPVT,2 digoxin toxicity, and long QT syndrome type 7 (Andersen-Tawil syndrome).3 It had also been rarely reported in subjects with sarcoidosis4 and acute coronary syndrome (ACS).5
Andersen-Tawil syndrome: Clinical presentation and predictors of symptomatic arrhythmias – Possible role of polymorphisms K897T in KCNH2 and H558R in SCN5A gene
2017, Journal of CardiologyCitation Excerpt :There are only few studies suggesting influence of flecainide on cardiac arrhythmias reduction but benefit of flecainide for prevention of medically significant cardiac arrhythmias is still unknown. Moreover, it is known that this drug causes many side effects often making treatment impossible [9,10]. A carrier could present only a part of the triad or even be asymptomatic [11].
Atrial pacing for the management of ventricular arrhythmias in Andersen-Tawil syndrome
2015, HeartRhythm Case ReportsImipramine for incessant ventricular arrhythmias in 2 unrelated patients with Andersen-Tawil syndrome
2015, Heart RhythmCitation Excerpt :β-Blockers have no effect as pointed out by most reports.8 Erdogan et al,15 Sumitomo et al,16 and Kannankeril et al17 have all reported using verapamil to control complex VT in patients with ATS. In those reports, frequent ectopy continued despite the decrease in runs of VT.
Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations
2015, Heart RhythmCitation Excerpt :Bokenkamp et al13 reported that β-blockers, the mainstay for other types of long QT syndrome, are ineffective for the suppression of VAs in patients with ATS. Similarly, the efficacy of calcium channel blockers is uncertain; in addition, calcium channel blockers have risk of torsades de pointes and syncope in patients with ATS.10,11,13 In this study, although β-blockers and/or calcium channel blockers were administered in 6 patients to prevent VAs, these drugs could not suppress VAs.
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Dr. Shimizu was supported by health sciences research grants (H18-Research on Human Genome-002) from the Ministry of Health, Labour and Welfare, Japan.