Immunity
Volume 32, Issue 2, 26 February 2010, Pages 253-265
ArticleOptimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84
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Graphical Abstract
Highlights
► Sustained T cell:B cell adhesion requires both integrin- and SAP-dependent pathways ► SAP-associated receptors CD84 and Ly108 are expressed on follicular T helper cells ► CD84 is required for optimal germinal center formation and T cell:B cell adhesion ► Multiple SAP-associated SLAM receptors help mediate T cell:B cell interactions in vitro
MOLIMMUNO
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Present address: Tsinghua University School of Medicine, Beijing 100084, P.R. China
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