EditorialInvolvement of the innate immune system in liver regeneration and injury
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Cited by (49)
Kupffer cells and liver
2022, Recent Advancements in Microbial Diversity: Macrophages and their Role in InflammationLKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration
2018, Cell ReportsCitation Excerpt :We investigated the contribution of LKB1 to hepatocyte proliferation during liver growth, by performing a two-thirds partial hepatectomy (PHx) on age- and sex-matched Lkb1 hepatocyte-specific knockout mice (Lkb1Δhep) and control littermates (CTR) (Figure 1A). PHx in mice triggers a synchronized wave of cell cycling and growth in the remnant liver, restoring liver size to presurgical levels (Fausto, 2006). Almost all hepatocytes divide soon after PHx (between 0 and 48 hr after surgery).
Bioinformatics microarray analysis and identification of gene expression profiles associated with cirrhotic liver
2016, Kaohsiung Journal of Medical SciencesCitation Excerpt :Additionally, few genes related to the ECM remodeling pathway were significant in cirrhotic liver, which is consistent with previous reports that showed a connection between liver cirrhosis and process of apoptosis, cell repair, wound healing, and cell proliferation [12,13,31]. Although innate immunity has been described to be important for liver regeneration [32–34], few genes involved in liver regeneration were differentially expressed in the cirrhotic liver of this study. Meanwhile, a number of genes associated with metabolic liver functions such as bile acid metabolism and protein metabolism were markedly decreased in the cirrhotic liver compared to the healthy liver.
Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts
2015, Veterinary JournalCitation Excerpt :LPS is very important for normal hepatic regeneration (Cornell, 1985a, 1985b; Cornell et al., 1990; Gao et al., 1999). Kupffer cell release of IL-6 and TNFα in response to LPS is implicated in the initiation of hepatic regeneration (Fausto, 2006). Increased expression of TLR4 mRNA suggests increased LPS binding capacity in dogs with CPSS and good portal blood flow and in those able to tolerate complete attenuation.
Cascades of transcription regulation during liver regeneration
2011, International Journal of Biochemistry and Cell BiologyC-terminal peptide of anaphylatoxin C3a enhances hepatic function after steatotic liver transplantation: A study in a rat model
2010, Transplantation Proceedings