Oral and maxillofacial pathologyAnaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation
Section snippets
Case Report
A 48-year-old Hispanic male presented with a one-year history of increased temporal swelling, left eye pain, and proptosis for which he wore protective safety glasses. The patient was originally treated 10 years earlier for AF of the maxilla with left infrastructure (partial) maxillectomy. Subsequently, he underwent unknown surgical procedures for probable recurrence reported 4 years after initial surgery. Rapid growth and a marked increase in proptosis was noted before his current admission (
Discussion
We report a rare example of anaplastic sarcomatous development in an AF 10 years after the primary excision. The tumor manifested heterogeneous cellular features including low-grade spindled, epithelioid, and undifferentiated malignant components. The phenotypic spectrum of malignant sarcomatous features in our case is distinctly different from those previously reported 3, 6 and suggests progressive transformation from the benign spindle cells of the primary lesion. We contend that phenotypic
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Ameloblastic fibrosarcoma – A rarity?
2019, JPRAS OpenCitation Excerpt :An alteration in the p53 gene has been reported in the malignant counterpart.8 AFS shows male predilection, with posterior mandible as the most common site of occurrence.13 A 33-year-old male patient reported to the Department of Oral and Maxillofacial Surgery, with a complaint of pain and swelling on the left side of the face for the past 9 months.
A case of a huge mandibular tumor composed of ameloblastoma and high-grade sarcoma
2019, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCitation Excerpt :This indicates that the present tumor was not an ameloblastic carcinoma either. Ameloblastic fibrosarcoma is regarded as the malignant counterpart of the benign ameloblastic fibroma [5,6]. The mesenchymal tissue surrounding the epithelial component shows histological evidence of malignancy while the epithelial component appears bland.
Ameloblastic Fibrosarcoma of the Mandible: A Case Report and a Review of the Literature
2015, Journal of Oral and Maxillofacial SurgeryCitation Excerpt :AFS can arise de novo10 or can transform from a pre-existing benign lesion, such as AF, ameloblastic fibro-odontoma, or odontoameloblastoma.11-14 Because patients with AFS are typically 10 years older than those with AF, it is hypothesized that this occurs through a stepwise malignant transformation.14 More than 50% of reported cases had histologic documentation of AF in the same site, providing supporting evidence of malignant transformation.3
Ameloblastic fibrosarcoma developing 8 years after resection of ameloblastic fibro-dentinoma: A unique presentation
2015, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyFibrosarcome améloblastique : Une tumeur odontogène maligne rare
2014, Annales Francaises d'Oto-Rhino-Laryngologie et de Pathologie Cervico-FacialeAmeloblastic fibrosarcoma: A rare malignant odontogenic tumor
2014, European Annals of Otorhinolaryngology, Head and Neck Diseases