Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

Abstract

Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications not only for carcinogenesis by RNA viruses but also for the general understanding of genetic transcription: apparently the classical process of information transfer from DNA to RNA can be inverted.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Green, M., Ann. Rev. Biochem., 39 (1970, in the press).

  2. Temin, H. M., Virology, 23, 486 (1964).

    Article  CAS  Google Scholar 

  3. Bader, J. P., Virology, 22, 462 (1964).

    Article  CAS  Google Scholar 

  4. Vigier, P., and Golde, A., Virology, 23, 511 (1964).

    Article  CAS  Google Scholar 

  5. Duesberg, P. H., and Vogt, P. K., Proc. US Nat. Acad. Sci., 64, 939 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Temin, H. M., in Biology of Large RNA Viruses (edit. by Barry, R., and Mahy, B.) (Academic Press, London, 1970).

    Google Scholar 

  7. Temin, H. M., Virology, 20, 577 (1963).

    Article  CAS  Google Scholar 

  8. Kates, J. R., and McAuslan, B. R., Proc. US Nat. Acad. Sci., 58, 134 (1967).

    Article  ADS  CAS  Google Scholar 

  9. Munyon, W., Paoletti, E., and Grace, J. T. J., Proc. US Nat. Acad. Sci., 58, 2280 (1967).

    Article  ADS  CAS  Google Scholar 

  10. Shatkin, A. J., and Sipe, J. D., Proc. US Nat. Acad. Sci., 61, 1462 (1968).

    Article  ADS  CAS  Google Scholar 

  11. Borsa, J., and Graham, A. F., Biochem. Biophys. Res. Commun., 33, 895 (1968).

    Article  CAS  Google Scholar 

  12. Baltimore, D., Huang, A. S., and Stampfer, M., Proc. US Nat. Acad. Sci. 66 (1970, in the press).

  13. Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970) (following article).

    Article  ADS  CAS  Google Scholar 

  14. O'Conner, T. E., Rauscher, F. J., and Zeigel, R. F., Science, 144, 1144 (1964).

    Article  ADS  Google Scholar 

  15. Crawford, L. V., and Crawford, E. M., Virology, 13, 227 (1961).

    Article  CAS  Google Scholar 

  16. Duesberg, P., and Robinson, W. S., Proc. US Nat. Acad. Sci., 55, 219 (1966).

    Article  ADS  CAS  Google Scholar 

  17. Duff, R. G., and Vogt, P. K., Virology, 39, 18 (1969).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BALTIMORE, D. Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses. Nature 226, 1209–1211 (1970). https://doi.org/10.1038/2261209a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2261209a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing