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  • Clinical Context
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Untangling the heavy cardiovascular burden of obesity

Abstract

This article sets out the clinical context of the research presented by Romero-Corral et al. in an accompanying article in this journal. Obesity is an important risk factor for the development of cardiovascular disease. Among other metabolic abnormalities, obesity is associated with elevated levels of the inflammatory biomarker C-reactive protein (CRP) and of leptin. Here, we discuss the study carried out by Romero-Corral and colleagues—an analysis of leptin, CRP and cardiovascular risk factors. These researchers found that raised leptin concentrations were a more robust predictor of cardiovascular events than CRP; the highest risk was observed in participants with raised concentrations of both markers. We explore the possible mechanism for this interaction, and propose that leptin's stimulatory effect on the sympathetic nervous system and its ability to impair baroreceptor control might be involved.

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References

  1. Lavie CJ et al. (2007) Obesity, heart disease, and favorable prognosis—truth or paradox? Am J Med 120: 825–826

    Article  Google Scholar 

  2. Ross R (1999) Atherosclerosis—an inflammatory disease. N Engl J Med 340: 115–126

    Article  CAS  Google Scholar 

  3. Zwaka TP et al. (2001) C-reactive protein-medicated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation 103: 1194–1197

    Article  CAS  Google Scholar 

  4. Milani RV et al. (2004) Reduction in C-reactive protein through cardiac rehabilitation and exercise training. J Am Coll Cardiol 43: 1056–1061

    Article  CAS  Google Scholar 

  5. Romero-Corral et al. (2008) Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat Clin Pract Cardiovasc Med [doi:10.1038/ncpcardio1218]

    Article  CAS  Google Scholar 

  6. Unger RH and Elmquist JK (2006) Movin' on up: adipocytes become regulators of nutrient homeostasis. Cell Metab 3: 147–148

    Article  CAS  Google Scholar 

  7. Chen K et al. (2006) Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 12: 425–432

    Article  CAS  Google Scholar 

  8. Ridker PM et al.; Pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 (PROVE IT-TIMI 22) Investigators (2005). C-reactive protein levels and outcomes after statin therapy. N Engl J Med 352: 20–28

    Article  CAS  Google Scholar 

  9. Yang R and Barouch LA (2007) Leptin signaling and obesity: cardiovascular consequences. Circ Res 101: 545–559

    Article  CAS  Google Scholar 

  10. Esler M et al. (2006) Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48: 787–796

    Article  CAS  Google Scholar 

  11. Grassi G and Elam M (2002) Leptin, sympathetic and baroreflex function: another step on the road to sympathetic differentiation. J Hypertens 20: 1487–1489

    Article  CAS  Google Scholar 

  12. Gertler A (2006) Development of leptin antagonists and their potential use in experimental biology and medicine. Trends Endocrinol Metab 17: 372–378

    Article  CAS  Google Scholar 

  13. Blair SN and Church TS (2004) The fitness, obesity, and health equation. Is physical activity the common denominator? JAMA 292: 1232–1234

    Article  CAS  Google Scholar 

Download references

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Correspondence to Carl J Lavie.

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The authors declare no competing financial interests.

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Lavie, C., Milani, R. & Ventura, H. Untangling the heavy cardiovascular burden of obesity. Nat Rev Cardiol 5, 428–429 (2008). https://doi.org/10.1038/ncpcardio1257

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