Abstract
We identified specialized B helper and tissue inflammatory CD4+ T cell subsets that developed concurrently from common naïve precursors during the primary immune response. These separable populations were distinguishable by their expression of adhesion and chemoattractant receptors that directed their homing to the appropriate effector sites in vivo and also showed intrinsic differences in their ability to support B cell antibody production and produce effector cytokines in vitro. Thus, our data show a previously unappreciated functional specialization among CD4+ effector T cells, further defining their diversity and role in adaptive immunity.
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Acknowledgements
We thank L. Rott for cell sorting and J. Allison, J. Cyster, D. Soler, J. B. Lowe, O. Kanagawa and D. Umetsu for providing invaluable reagents. Supported by grants from the National Institutes of Health (E.C. B. and D. J. C.); an award from the Department of Veterans Affairs (E. C. B.); the FACS Core Facility of the Stanford Digestive Disease Center; the Arthritis Foundation (D. J. C.); and the Leukemia and Lymphoma Society (C. H. K.).
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Campbell, D., Kim, C. & Butcher, E. Separable effector T cell populations specialized for B cell help or tissue inflammation. Nat Immunol 2, 876–881 (2001). https://doi.org/10.1038/ni0901-876
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DOI: https://doi.org/10.1038/ni0901-876
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