Risks associated with transfusion of cellular blood components in canada*,☆☆,★,★★
Section snippets
Measurement of risk
The simplest means of determining risk is by clinical case reporting of adverse reactions or effects*after transfusion. Unfortunately, clinical case reporting has several
Literature review
The Medline database was searched using the following general and specific key terms: transfusion reaction, transfusion error, adverse transfusion event, transfusion complication, febrile nonhemolytic transfusion reaction, transfusion allergic reaction, transfusion anaphylactic reaction, hemolytic transfusion reaction, ABO errors, transfusion and volume/circulatory overload, transfusion-related acute lung injury, transfusion-associated graft versus host disease, posttransfusion purpura,
Infectious risks
An important aspect of assessing the infectious risks of transfusion is the distinction between the risk of transmission of the agent and that of clinically significant disease, which generally occurs only in a percentage of those who become infected. Many agents (eg, HIV, HCV, and human T-cell lymphotropic virus [HTLV]) produce clinical disease only many years after the initial infection. It is obvious that the deleterious effects of these agents will occur in fewer patients than would be
Hemolytic transfusion reactions
A hemolytic transfusion reaction consists of an accelerated destruction of red blood cells because of incompatibility between the donor and the recipient. Red cell hemolysis can also occur because of nonimmunological causes like overheating of the blood unit and mechanical damage to the cells because of extracorporeal circulation devices or aging of red cell units during storage. These rare events can also cause reactions, but they are not included in this review. Hemolytic transfusion
Summary of risks of transfusion in Canada
The risks of clinically symptomatic noninfectious and infectious adverse reactions in Canada are summarized in Tables 9 (non-infectious risks) and 10 (infectious risks).The far right-hand columns of these tables project the annual number of cases of each reaction that are expected to occur in Canada assuming 780,000 red cell units and 350,000 platelets (70,000 platelet pools) are transfused annually.
The noninfectious risk estimates in this review were taken either from the published literature
Acknowledgements
The authors thank Dr Graham Sher, Canadian Blood Services; Dr Francine Décary, Héma-Québec; and Julia Hill, Health Canada for approving release of data from their respective organizations for purposes of this review. We• would also like to thank Dr Heather Hume, Dr Vito Scalia, Dr Joanne Chiavetta, Dr Shelley Deeks, Tom Walker, and Pina Guidoccio from Canadian Blood Services; Dr Mindy Goldman and Dr Marc Germain from Héma-Québec; and Dr Peter Ganz and Dr Farid Hindieh from Health Canada who
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Determining the true incidence of acute transfusion reactions: Active surveillance at a specialized liver center
2020, Hematology, Transfusion and Cell TherapyCitation Excerpt :The major hurdles in adequate reporting of TRs include: 1) lack of understanding/ awareness of the HvP among clinicians, 2) lack of a culture of reporting adverse events, 3) fear of punishment and 4) lack of experts/expertise on hemovigilance.18 The HvPs rely on passive reporting.7–11 Studies have shown that active reporting systems report higher rates of transfusion reactions than passive ones.13–15
Propensity and impact of autologous platelet rich plasma use in acute type A dissection
2020, Journal of Thoracic and Cardiovascular SurgeryImpact of Autologous Blood Transfusion on Survival and Recurrence among Patients Undergoing Partial Hepatectomy for Colorectal Cancer Liver Metastases
2019, Journal of the American College of SurgeonsPredictors and outcomes of perioperative blood transfusions in classic bladder exstrophy repair: A single institution study
2018, Journal of Pediatric Urology
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This document represents the work of individuals and is not an official document of the National Blood Safety Council or the Quebec Public Health Institute.
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Funded by an unrestricted educational grant from the Hemosol Corporation.
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Address reprint requests to Steven Kleinman, MD, 1281 Rockcrest Avenue, Victoria, BC, V9A-4W4 Canada.
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