American Journal of Orthodontics and Dentofacial Orthopedics
Original ArticleOrthodontic treatment in long-term survivors after pediatric bone marrow transplantation*,**,*,**,*
Section snippets
Material and methods
From 1975 to 1995, 190 children (< 12 years of age) were treated with BMT at Huddinge University Hospital in Sweden. Details of their medical and dental treatments have been reported by Näsman et al.19 Of these children, 106 survived more than 2 years. All the children had an oral examination before BMT and then annually in the Department of Pediatric Dentistry, Karolinska Institutet in Stockholm. The children came from all parts of Sweden, and their dental treatments were performed at local
Results
Generally, very few harmful effects as a result of orthodontic therapy were reported in these children with severe disturbances in dental development. Five orthodontists reported that the choice of therapy and the treatment plan were influenced by the patient's condition. The patients had all been treated with 10 Gy TBI and exhibited the most severe disturbances in root development. Orthodontic treatments for 3 patients were delayed because of their previous medical conditions. One orthodontist
Discussion
Disturbed dental development in children treated with BMT has been reported in several studies, but information about orthodontic treatment outcomes in these patients is still lacking. This information is urgently needed, because the population of long-term survivors after pediatric malignancies is increasing. With the treatment protocols available today, about 85% of children less than 15 years of age diagnosed with cancer survive at least 5 years.24
Long-term survivors of BMT, particularly
Acknowledgements
We thank these contributing orthodontists: Christer Engström, Gällivare; Anders Fischer, Nyköping; Carl-Magnus Forsberg, Stockholm; Sven Glantz, Eskilstuna; Bernt-Arne Larsson, Luleå; Gösta Lindgren, Kristianstad; Ulf Ljungberg, Skeppslanda; Ola Mörndal, Västerås; Bengt Schön, Arvika; and Håkan Westerling, Kalmar.
References (31)
- et al.
Risk factors for salivary dysfunction in children one year after allogeneic bone marrow transplantation
Eur J Cancer Oral Oncol
(1997) - et al.
Oral complications in children with cancer
Oral Surg Oral Med Oral Pathol
(1993) - et al.
Dental parameters in long-term survivors of childhood cancer compared with siblings
Oral Oncol
(1997) - et al.
The oral health of long-term survivors of acute lymphoblastic leukaemia: a comparison of three treatment modalities
Eur J Cancer
(1995) - et al.
Disturbances in dental development after total body irradiation in bone marrow transplant recipients
Oral Surg Oral Med Oral Pathol
(1988) - et al.
Orthodontic management of patients with hematological malignancies
Am J Orthod Dentofacial Orthop
(1996) - et al.
Long-term evaluation of root resorption occurring during orthodontic treatment
Am J Orthod Dentofacial Orthop
(1989) - et al.
The medical cost of cure: sequelae in survivors of childhood
- et al.
Cardiac disease following treatment of Hodgkin's disease in children and adolescents
J Clin Oncol
(1993) - et al.
Second neoplasms after acute lymphoblastic leukemia in childhood
N Engl J Med
(1991)
A longitudinal study of growth and growth hormone secretion in children during treatment for acute lymphoblastic leukemia
Med Pediatr Oncol
Endocrine problems in children after bone marrow transplant for hematologic malignancies
Bone Marrow Transplant
Growth and growth hormone secretion after bone marrow transplantation
Arch Dis Child
Reduced bone mineral density in long-term survivors of childhood acute lymphoblastic leukemia
J Pediatr Hematol Oncol
Severe osteopenia and vertebral compression fractures after complete remission in an adolescent with acute leukemia
Am J Hematol
Cited by (44)
Cervico-facial irradiation and orthodontic treatment
2015, International OrthodonticsCitation Excerpt :the radiation dose: doses of between 10 and 30 Gy have a significant impact on bone growth and tooth development. Thirty grays (30 Gy) is potentially harmful for the development of cranio-facial structures; 4 Gy modifies soft tissue development [2,4,5]. Several different studies [2,7–9] on the effect of radiation on skeletal growth all agree that growth is suppressed by radiation, as in the case of irradiation of the head prescribed for the treatment of ALL.
Dental disorders in patients recovered from malignant neoplasms in childhood
2021, Russian Journal of Pediatric Hematology and Oncology
- *
Supported by grants from the Swedish Children's Cancer Foundation and the Swedish Medical Research Council.
- **
aProfessor of Pediatric Dentistry.
- *
bPostgraduate student, Pediatric Dentistry.
- **
cVisiting Professor of Orthodontics, from the Department of Preventive Dentistry, National University of Singapore.
- *
Reprint requests to: G. Dahllöf, Department of Pediatric Dentistry, Karolinska Institutet, PO Box 4064, SE 141 04, Huddinge, Sweden; e-mail, [email protected].