Elsevier

Journal of Thoracic Oncology

Volume 8, Issue 10, October 2013, Pages 1282-1288
Journal of Thoracic Oncology

Original Articles
Outcome and Prognostic Factors in Bronchial Carcinoids: A Single-Center Experience

https://doi.org/10.1097/JTO.0b013e31829f097aGet rights and content
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Introduction

The aim of this study is to assess factors influencing survival in patients with bronchial carcinoids (BCs).

Methods

A retrospective review of our surgical database of patients operated for primary lung cancer with a final histologic diagnosis of BC in the period from January 1, 1995 to December 31, 2010 was carried out.

Results

There were 126 patients (74 women): 83 had a typical carcinoid and 43 an atypical one (AC). All patients received a radical resection; systematic lymphadenectomy was accomplished in 120. Lymph nodal metastases were observed in 26 cases (12 N2) and were more frequent in ACs (p = 0.009). Twelve patients received adjuvant therapy (chemo/radio/biological). Distant metastases (DM) and local tumor recurrence occurred in 28 (22%) and 8 (6.3%) cases, respectively: DM were more frequent in ACs (p = 0.0001) and in N2 patients (p = 0.0001). Smoke, atypical histology, lymph nodal metastases, and high cellular proliferative index demonstrated to be statistically negative prognostic factors.

Conclusion

Even if characterized by an indolent behavior, BCs may spread to lymph node or distant or present with local recurrence. Amid all prognostic factors, the presence of DM demonstrated to be the strongest negative one.

Key Words

Typical carcinoid
Atypical carcinoid
Lymph nodal metastases
Neuroendocrine tumors
Distant metastases
Prognostic factors

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Disclosure: The authors declare no conflict of interest.