Chest
Communications to the EditorLactic Acidosis Associated With Propofol
Section snippets
To the Editor
Propofol is a short-acting IV anesthetic agent used for induction of general anesthesia and sedation of mechanically ventilated patients.1, 2 Propofol has a rapid onset and termination of action making it attractive for use in the ICU. Adverse effects include hypotension, green discoloration of urine, sepsis, and anaphylactoid reactions.1, 2, 3 This letter describes a patient with severe asthma who required mechanical ventilation and temporarily developed lactic acidosis while being sedated
REFERENCES (5)
- et al.
Comparison of propofol and midazolam for sedation in critically ill patients
Lancet
(1989) - et al.
Fatal metabolic acidosis in a pediatric patient receiving an infusion of propofol in the intensive care unit: is there a relationship?
Crit Care Med
(1995)
Cited by (63)
Propofol infusion syndrome: a structured literature review and analysis of published case reports
2019, British Journal of AnaesthesiaCitation Excerpt :An unpublished trial conducted by the manufacturers in 1999 led the FDA and the Canadian Health Board to request that the product label should recommend that propofol was not to be used for long-term sedation in paediatric patients.4 The first case reported in adults involved a patient with an exacerbation of asthma receiving long-term sedation for mechanical ventilation of the lungs.34 The first reported adult death attributed to propofol infusion syndrome occurred in 1998.35
Why is lactate important in critical care?
2019, Evidence-Based Practice of Critical CarePropofol infusion syndrome
2010, Annales Francaises d'Anesthesie et de ReanimationPerioperative suspicious propofol infusion syndrome: a case report
2023, Academic Journal of Naval Medical University