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Original ResearchPulmonary Function and Abdominal Adiposity in the General Population
Section snippets
Study Subjects
We recruited participants from Erie and Niagara counties in western New York, as previously described.17 In brief, we recruited a sample of the general population using lists supplied by the New York State Department of Motor Vehicles (respondents aged 35 to 65 years) and the Health Care Financing Administration (respondents aged > 65 years). We used letters and telephone contact to recruit participants. All study protocols were approved by the University at Buffalo institutional review board.
Results
The mean age of participants in the sample was 56.8 years (SD, 11.3 years) for women and 58.5 years (SD, 12.5 years) for men. Approximately 6.5% of all participants were African-American. Raw FEV1 and FVC values were higher for men, but once we removed the effects of age, height, and race, FEV1 percent predicted and FVC percent predicted values were higher for women (p < 0.001). More women in our sample were current smokers, but men had a higher lifetime exposure to cigarettes (p < 0.001). The
Discussion
We investigated the relation of a number of adiposity markers with pulmonary function in a population-based study. We found inverse associations of abdominal height and waist circumference with pulmonary function in men and women with BMI values of ≥ 25 kg/m2. Abdominal height and waist circumference explained the greatest proportion of variance in FEV1 and FVC relative to other markers of adiposity. Also, the inverse association of abdominal height and pulmonary function was evident only in
Conclusion
We found negative associations of abdominal adiposity and pulmonary function in men and women from the general population that are not limited to severely obese persons. Abdominal adiposity is an important determinant of impaired pulmonary function, and it is of greater importance than overall adiposity markers such as weight and BMI. We suggest that investigators consider the inclusion of markers of abdominal adiposity as a potential confounding factor when investigating the determinants of
ACKNOWLEDGMENT
We thank Richard W. Browne in the Department of Clinical Laboratory Science at the University at Buffalo for laboratory measurements. We would also like to thank the personnel at the Center for Preventive Medicine, University at Buffalo, for their contribution to the study.
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Drs. Ochs-Balcom, Grant, Muti, Freudenheim, Trevisan, Cassano, and Schünemann disclose that they have received no financial support or had involvement with organizations with a financial interest in the subject matter of this study.