Chest
Left Atrial Abnormalities Indicating Diastolic Ventricular Dysfunction in Cardiopathy of Obesity
Section snippets
SUBJECTS AND METHODS
Twelve obese normotensive and 20 obese patients with mild established essential hypertension were matched for mean arterial pressure, age, and sex with an equal number of lean patients, either hypertensive or normotensive. Thus, there were 12 pairs of lean and obese normotensive subjects and 20 pairs of lean and obese patients with established essential hypertension. Patients were considered to have established essential hypertension if their diastolic blood pressure on an outpatient basis was
RESULTS
When compared to lean patients with similar arterial pressure, obese patients had, as previously reported,2 greater ventricular end-diastolic (p<0.01) and end-systolic (p<0.05) diameters, left atrial dimension (p<0.01), and left atrial dimension index (p<0.05), posterior wall thickness (p<0.01), septal thickness (p<0.01), left ventricular mass (p<0.01) and left ventricular mass index (p<0.05) (Table 2). Left ventricular systolic function as determined by fractional fiber shortening and velocity
DISCUSSION
The present study demonstrates that obese patients, when compared to lean subjects, have a greater prevalence of electrocardiographic left atrial abnormality and have larger left atrial diameters independent of the level of arterial pressure. The left atrial emptying index was only slightly reduced in lean hypertensives and was reduced by 15 percent in all hypertensive compared to all normotensive subjects. However, the atrial emptying index, an indicator of early diastolic ventricular filling
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Presented in part at the 58th Scientific Session, American Heart Association, November 11-14, 1985, Washington, DC; and at the 36th Scientific Session, American College of Cardiology, March 8-12, 1987, New Orleans.
Manuscript received March 6; revision accepted May 18.