Abstract
SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.
MeSH terms
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Animals
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Aorta / drug effects
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Aorta / physiology
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Enzyme Activators / chemical synthesis
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Enzyme Activators / chemistry
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Enzyme Activators / pharmacology*
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Guanylate Cyclase / metabolism*
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Indazoles / chemical synthesis
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Indazoles / chemistry
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Indazoles / pharmacology*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology
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Pyridines / chemistry
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Pyridines / pharmacology
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Rabbits
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Structure-Activity Relationship
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Vasodilation / drug effects
Substances
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3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
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Enzyme Activators
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Indazoles
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Pyrazoles
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Pyridines
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3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
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Guanylate Cyclase