For patients with cancer it is essential to reach a definite diagnosis, obtain accurate staging and provide appropriate initial treatment if a successful outcome is to be achieved. These fundamental first steps in multidisciplinary care require close cooperation between surgical oncologists and pathologists. The most important aspect of this cooperation is clear and free exchange of information between them. The surgeon should provide the pathologist not only with an adequate tissue sample for examination, but also with clinical details that will assist in establishing a diagnosis. The location and orientation of specimens, and areas of particular concern, should always be indicated. Operative digital photographs may assist this process. The pathologist, in return, should provide the surgeon with a report containing sufficient information to allow an evidence-based management plan to be made for the patient, and to permit an accurate indication of prognosis to be determined. Use of a disease-specific synoptic report format will ensure that potentially important information is not overlooked. When there is diagnostic uncertainty, the pathologist should make this clear, but provide a preferred diagnosis. Further opinions may be helpful. If doubt exists, medico-legal considerations should not encourage a pathologist to issue a report with a diagnosis of malignancy. The pathologist should refrain from making management recommendations, because there may be valid reasons for the surgeon not providing this management. By cooperating fully and communicating freely with each other, surgical oncologists and pathologists can ensure high standards of initial and subsequent care for cancer patients.