VEGF receptor signalling - in control of vascular function

Nat Rev Mol Cell Biol. 2006 May;7(5):359-71. doi: 10.1038/nrm1911.

Abstract

Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Embryonic Development
  • Humans
  • Neovascularization, Physiologic*
  • Receptors, Vascular Endothelial Growth Factor / metabolism*
  • Signal Transduction*
  • Stem Cells / cytology
  • Vascular Endothelial Growth Factors / metabolism

Substances

  • Vascular Endothelial Growth Factors
  • Receptors, Vascular Endothelial Growth Factor