The intersection syndrome, described since the 19th century, is an uncommon disorder associated with the abductor pollicis longus and extensor pollicis brevis bellies (first dorsal compartment) rubbing against the extensor carpi radialis longus and brevis tendons (second dorsal compartment). Overuse occurred in occupational setting was barely described although it could lead to compensation by the French health insurance system. We reported a case of an intersection syndrome in a 58-year-old man who recently became a supermarket cashier. This job involved repeated extension and flexion of the wrist. The disorders arose after a minimal traumatism. Since it is recognized as an occupational disease, compensated ending of the activity causing the disorder could have been obtained.