This article details the first reported case of neonatal osteomyelitis caused by a nonhemolytic group B streptococcus. The identification of the organism was delayed due to the lack of hemolysis on blood agar plates. Therefore, the infant was treated with a more toxic regimen of antibiotics than would have otherwise been indicated. Successful treatment of this nonhemolytic group B streptococcal osteomyelitis included a combination of both parenteral and oral antibiotics. Proper identification of nonhemolytic streptococcal infections in the infant is essential to ensure safe and accurate antibiotic treatment.