Rituximab-vincristine chemotherapy-induced acute anterior wall myocardial infarction with cardiogenic shock

Tex Heart Inst J. 2014 Feb;41(1):80-2. doi: 10.14503/THIJ-12-2853.

Abstract

We present a case of an elderly man with coronary artery disease who was diagnosed with non-Hodgkin lymphoma. Soon after the administration of chemotherapy, which included rituximab and vincristine, he developed acute myocardial infarction with cardiogenic shock. The condition was managed successfully with primary percutaneous coronary intervention. We briefly discuss the possible pathogenic mechanisms of chemotherapy-induced ischemic syndrome and the management of chemotherapy in patients with high cardiovascular risk.

Publication types

  • Case Reports
  • Video-Audio Media

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / instrumentation
  • Anterior Wall Myocardial Infarction / chemically induced*
  • Anterior Wall Myocardial Infarction / diagnosis
  • Anterior Wall Myocardial Infarction / therapy
  • Antibodies, Monoclonal, Murine-Derived / administration & dosage
  • Antibodies, Monoclonal, Murine-Derived / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Coronary Angiography
  • Coronary Artery Disease / complications
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / therapy
  • Humans
  • Lymphoma, Non-Hodgkin / complications
  • Lymphoma, Non-Hodgkin / drug therapy*
  • Male
  • Risk Factors
  • Rituximab
  • Shock, Cardiogenic / chemically induced*
  • Shock, Cardiogenic / diagnosis
  • Shock, Cardiogenic / therapy
  • Stents
  • Treatment Outcome
  • Vincristine / administration & dosage
  • Vincristine / adverse effects

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Rituximab
  • Vincristine